Journal article
Suboptimal sleep efficiency and duration predicts rate of accumulation of Aβ‐ Amyloid in cognitively normal older adults
Alzheimer's & Dementia, Vol.18(S6), e060975
2022
Abstract
Background
There is increasing evidence of a bidirectional relationship between suboptimal sleep and brain Aβ‐amyloid (Aβ) accumulation. Suboptimal sleep is suggested to both result from and contribute to the accumulation of brain Aβ. This study tested whether aspects of self‐reported sleep quality predict the longitudinal accumulation of brain Aβ.
Method
Linear mixed effect model analyses were conducted on 192 cognitively normal older adults (M = 73.8 years, SD = 5.8, 51.6% female). These individuals, drawn from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing, had self‐reported sleep characteristics assessed at baseline and positron emission tomography‐determined brain Aβ burden measured over a minimum of three AIBL timepoints (range 33.3‐73.9 months). Analyses included random slopes and intercepts, interaction for apolipoprotein E (APOE) ε4 allele status and time, adjusting for sex and baseline age.
Result
Sleep duration of <5 hours and sleep efficiency of <65% both significantly forecast the longitudinal trajectory of Aβ accumulation in the whole cohort (sleep duration <5 hrs β = 4.70 ± 1.58, p = 0.003; sleep efficiency <65% β = 2.94 ± 0.91, p = 0.001) and in APOE ε4 non‐carriers (sleep duration <5 hrs β = 4.70 ± 1.53, p = 0.003; sleep efficiency <65% β = 2.90 ± 0.87, p = 0.001) but not in APOE ε4 carriers.
Conclusion
These findings indicate a role for self‐reported suboptimal sleep efficiency and duration in the accumulation of Alzheimer's disease neuropathology in cognitively normal individuals. Individuals with suboptimal sleep may benefit from an intervention to improve these sleep parameters to lessen future Alzheimer's risk. Our findings also suggest the potential utility of self‐report screening for sleep efficiency and duration as a predictor of risk of Aβ accumulation.
Details
- Title
- Suboptimal sleep efficiency and duration predicts rate of accumulation of Aβ‐ Amyloid in cognitively normal older adults
- Authors/Creators
- Louise N Pivac - Murdoch UniversityBelinda M Brown - Murdoch UniversityKelsey R Sewell - Murdoch UniversityJames D Doecke - Commonwealth Scientific and Industrial Research OrganisationVictor L Villemagne - University of PittsburghVincent Dore - Austin HealthMichael Weinborn - The University of Western AustraliaHamid R Sohrabi - Murdoch UniversitySamantha L Gardener - Edith Cowan UniversityRomola S Bucks - The University of Western AustraliaColin L Masters - Florey Institute of Neuroscience and Mental HealthChristopher Rowe - Austin HealthRalph N Martins - Edith Cowan University (Australia, Bunbury) - ECUStephanie Rainey-Smith - Murdoch University
- Publication Details
- Alzheimer's & Dementia, Vol.18(S6), e060975
- Publisher
- Wiley
- Number of pages
- 1
- Identifiers
- 991005592876907891
- Copyright
- © 2022 the Alzheimer’s Association
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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