Journal article
Subtyping Cryptosporidium ubiquitum, a zoonotic pathogen emerging in humans
Emerging Infectious Diseases, Vol.20(2), pp.217-224
2014
Abstract
Cryptosporidium ubiquitum is an emerging zoonotic pathogen. In the past, it was not possible to identify an association between cases of human and animal infection. We conducted a genomic survey of the species, developed a subtyping tool targeting the 60-kDa glycoprotein (gp60) gene, and identified 6 subtype families (XIIa-XIIf) of C. ubiquitum. Host adaptation was apparent at the gp60 locus; subtype XIIa was found in ruminants worldwide, subtype families XIIb-XIId were found in rodents in the United States, and XIIe and XIIf were found in rodents in the Slovak Republic. Humans in the United States were infected with isolates of subtypes XIIb-XIId, whereas those in other areas were infected primarily with subtype XIIa isolates. In addition, subtype families XIIb and XIId were detected in drinking source water in the United States. Contact with C. ubiquitum-infected sheep and drinking water contaminated by infected wildlife could be sources of human infections.
Details
- Title
- Subtyping Cryptosporidium ubiquitum, a zoonotic pathogen emerging in humans
- Authors/Creators
- N. Li (Author/Creator)L. Xiao (Author/Creator)K. Alderisio (Author/Creator)K. Elwin (Author/Creator)E. Cebelinski (Author/Creator)R. Chalmers (Author/Creator)M. Santin (Author/Creator)R. Fayer (Author/Creator)M. Kvac (Author/Creator)U. Ryan (Author/Creator)B. Sak (Author/Creator)M. Stanko (Author/Creator)Y. Guo (Author/Creator)L. Wang (Author/Creator)L. Zhang (Author/Creator)J. Cai (Author/Creator)D. Roellig (Author/Creator)Y. Feng (Author/Creator)
- Publication Details
- Emerging Infectious Diseases, Vol.20(2), pp.217-224
- Publisher
- National Center for Infectious Diseases
- Identifiers
- 991005543771407891
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.246 Diarrheal Diseases
- 1.246.985 Cryptosporidium
- Web Of Science research areas
- Immunology
- Infectious Diseases
- ESI research areas
- Immunology