Journal article
Successful treatment of a clinical elephant endotheliotropic herpesvirus infection: The dynamics of viral load, genotype analysis, and treatment with acyclovir
Journal of Zoo and Wildlife Medicine, Vol.48(4), pp.1254-1259
2017
Abstract
This article describes the treatment of clinical elephant endotheliotropic herpesvirus (EEHV) infection in a male Asian elephant (Elephas maximus; approximately 3 yr old), the dynamics of viral load during the active infection, and genetic analysis of the virus. Treatment included injectable acyclovir (12 mg/kg iv, bid), antibiotic, vitamin, and fluids. Quantitative polymerase chain reaction was used to measure the viral levels in blood, which decreased continuously after initiation of intravenous acyclovir. Low levels of virus were detected in the blood for 2 wk, and the virus was undetectable after 1 mo. No complication was observed during the treatment period. This case report suggests that acyclovir, given parenterally, could potentially enhance survival of clinical EEHV-infected individuals.
Details
- Title
- Successful treatment of a clinical elephant endotheliotropic herpesvirus infection: The dynamics of viral load, genotype analysis, and treatment with acyclovir
- Authors/Creators
- S. Sripiboon (Author/Creator)T. Angkawanish (Author/Creator)K. Boonprasert (Author/Creator)P. Sombutputorn (Author/Creator)W. Langkaphin (Author/Creator)W. Ditcham (Author/Creator)K. Warren (Author/Creator)
- Publication Details
- Journal of Zoo and Wildlife Medicine, Vol.48(4), pp.1254-1259
- Publisher
- American Association of Zoo Veterinarians
- Identifiers
- 991005542501007891
- Copyright
- © 2017 by American Association of Zoo Veterinarians
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.161 Virology - Identification & Sequencing
- 1.161.315 Herpesvirus Dynamics
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science