Sufficient vitamin D status positively modified ventilatory function in asthmatic children following a Mediterranean diet enriched with fatty fish intervention study

M.M. Papamichael; C. Itsiopoulos; K. Lambert; C. Katsardis; D. Tsoukalas; B. Erbas

doi:10.1016/j.nutres.2020.08.004

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Sufficient vitamin D status positively modified ventilatory function in asthmatic children following a Mediterranean diet enriched with fatty fish intervention study

Journal article

Peer reviewed

Sufficient vitamin D status positively modified ventilatory function in asthmatic children following a Mediterranean diet enriched with fatty fish intervention study

M.M. Papamichael, C. Itsiopoulos, K. Lambert, C. Katsardis, D. Tsoukalas and B. Erbas

Nutrition Research, Vol.82, pp.99-109

2020

DOI: https://doi.org/10.1016/j.nutres.2020.08.004

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Abstract

Asthma in children is the most prevalent allergic disease worldwide that has become a major public health priority. The objective of this study was to examine the relationship between baseline serum vitamin D status, spirometry, and fractional exhaled nitric oxide levels (FeNO) in 64 Greek children with ‘mild asthma’ aged 5 to 12 years (51.6% male) in a dietary intervention study. We hypothesized that baseline serum vitamin D levels modify the beneficial response of fatty fish intake on pulmonary function in asthmatic children following a Mediterranean diet. The intervention group consumed 2 fatty fish meals/week (≥150 g cooked filleted fish/meal) as part of the Mediterranean diet for six months, and the control group consumed their usual diet. Baseline serum 25(OH)D was determined using enzyme-linked immunoassay and defined as sufficient levels of 25(OH)D ≥25 ng/mL. Only 36% of children were graded as sufficient in 25(OH)D levels on entry into the study with a higher proportion of girls insufficient than boys (61% vs 39% respectively). Participants with sufficient levels of serum 25(OH)D at baseline, consuming the intervention diet increased FEV1/FVC by 4.89 units (β = 4.89; 95%CI: 1.19-8.61; p = 0.013) and FEF25-75% by 12.83 units (β = 12.83; 95%CI: 4.27-21.40; p = 0.006) compared to controls. No significant differences in pulmonary function or FeNO were observed for those with insufficient levels of 25(OH) D in the intervention or control groups. In conclusion, sufficient serum vitamin D levels enhanced ventilatory function in response to a dietary intervention in asthmatic children.

Details

Title: Sufficient vitamin D status positively modified ventilatory function in asthmatic children following a Mediterranean diet enriched with fatty fish intervention study
Authors/Creators: M.M. Papamichael (Author/Creator) - La Trobe University
C. Itsiopoulos (Author/Creator) - La Trobe University
K. Lambert (Author/Creator) - La Trobe University
C. Katsardis (Author/Creator) - National and Kapodistrian University of Athens
D. Tsoukalas (Author/Creator) - European Institute
B. Erbas (Author/Creator) - La Trobe University
Publication Details: Nutrition Research, Vol.82, pp.99-109
Publisher: Elsevier Inc.
Identifiers: 991005542137507891
Copyright: © 2020 Elsevier Inc.
Murdoch Affiliation: College of Science, Health, Engineering and Education
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.80 Bone Diseases; 1.80.279 Vitamin D
Web Of Science research areas: Nutrition & Dietetics
ESI research areas: Biology & Biochemistry