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Author’s VersionCC BY-NC-ND V4.0, Open Access
Journal article
Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories
Journal of Immunological Methods, Vol.416, pp.59-68
2015
Abstract
Extensive surface profiles of colorectal cancer (CRC) cells and tumor infiltrating lymphocytes (TIL) have been obtained from 45 surgical resection samples. Live cells were captured on an antibody microarray and stained with fluorescently-labeled antibodies. Minimal panels of 11 CRC antigens (CD13, CD24, CD26, CD49d, CD138, CD166, CA-125, CA19-9, EGFR, Galectin-4 and HLA-DR) and 11 T-cell antigens (CD10, CD11b, CD11c, CD25, CD31, CD95, CD151, CD181, Galectin-4, CA19-9, TSP-1) provide signatures for relapse and survival. Hierarchical clustering of profiles from CRC cells and TIL identified groups of patients for survival, systemic relapse and death. The groups from CRC and TIL profiles for systemic relapse showed 79.2% concordance, enabling prediction of relapse after surgery. The results demonstrate communication between CRC cells and TIL.
Details
- Title
- Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories
- Authors/Creators
- J. Zhou (Author/Creator) - The University of SydneyL. Belov (Author/Creator) - The University of SydneyP. Chapuis (Author/Creator) - Concord Repatriation General HospitalC. Chan (Author/Creator) - Concord Repatriation General HospitalN. Armstrong (Author/Creator) - The University of SydneyK.L. Kaufman (Author/Creator) - The University of SydneyM.J. Solomon (Author/Creator) - Royal Prince Alfred HospitalS.J. Clarke (Author/Creator) - Royal North Shore HospitalR.I. Christopherson (Author/Creator) - The University of Sydney
- Publication Details
- Journal of Immunological Methods, Vol.416, pp.59-68
- Publisher
- Elsevier BV
- Identifiers
- 991005540227707891
- Copyright
- © 2014 Elsevier B.V
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.108 Molecular & Cell Biology - Cancer & Development
- 1.108.591 Cancer Stem Cells
- Web Of Science research areas
- Biochemical Research Methods
- Immunology
- ESI research areas
- Immunology