Journal article
Swainsonine affects the processing of glycoproteins in vivo
FEBS Letters, Vol.163(1), pp.110-113
2001
Abstract
Rats, sheep and guinea pigs treated with swainsonine excrete 'high mannose' oligosaccharides in urine. The major rat and guinea pig oligosaccharide is (Man)5GlcNAc whereas sheep excrete a mixture of oligosaccharides of composition (Man)2-5GlcNAc2 and (Man)3-5GlcNAc. The presence of these oligosaccharides suggests that Golgi α-D-mannosidase II as well as lysosomal α-D-mannosidase is inhibited by swainsonine resulting in storage of abnormally processed asparagine-linked glycans from glycoproteins. Altered glycoprotein processing appears to have little effect on the health of the intoxicated animal, but the accompanying lysosomal storage produces a disease state.
Details
- Title
- Swainsonine affects the processing of glycoproteins in vivo
- Authors/Creators
- D.J. Abraham (Author/Creator) - Queen Elizabeth College, MauritiusR. Sidebothom (Author/Creator) - Queen Elizabeth College, MauritiusB.G. Winchester (Author/Creator) - Queen Elizabeth College, MauritiusP.R. Dorling (Author/Creator) - Murdoch UniversityA. Dell (Author/Creator) - Imperial College London
- Publication Details
- FEBS Letters, Vol.163(1), pp.110-113
- Publisher
- Elsevier
- Identifiers
- 991005540742607891
- Murdoch Affiliation
- School of Veterinary Studies
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
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- Citation topics
- 2 Chemistry
- 2.1 Synthesis
- 2.1.1145 Iminosugar Synthesis
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology
- ESI research areas
- Biology & Biochemistry