Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective

G.F. Watts; D.R. Sullivan; D.L. Hare; K.M. Kostner; A.E. Horton; D.A. Bell; T. Brett; R.J. Trent; N.K. Poplawski; A.C. Martin; S. Srinivasan; R.N. Justo; C.K. Chow; J. Pang; Z. Ademi; J.J. Ardill; W. Barnett; T.R Bates; L.J. Beilin; W. Bishop; J.A. Black; A. Brown; J.R. Burnett; C.A. Bursill; A. Colley; P.M. Clifton; E.I. Ekinci; G.A. Figtree; B.H. Forge; J. Garton-Smith; D.F. Graham; I. Hamilton-Craig; C.R. Hamilton-Craig; C. Heal; C.M. Hespe; A.J. Hooper; L.G. Howes; J. Ingles; E.D. Janus; N. Kangaharan; A.C. Keech; A.B. Kirke; L. Kritharides; C.V. Kyle; P. Lacaze; S.C.H. Li; S. Maticevic; B.M. McQuillan; S. Mirzaee; T.A. Mori; A.C. Morton; D.M. Colquhoun; J.C. Moullin; P.J. Nestel; K.J. Nowak; R.C. O'Brien; N. Pachter; M.M. Page; P.J. Psaltis; J. Radford; N.J. Reid; E.N. Robertson; J.D.M. Ryan; M.N. Sarkies; C.J. Schultz; R.S. Scott; C. Semsarian; L.A. Simons; C. Spinks; A.M. Tonkin; F. van Bockxmeer; K.E. Waddell-Smith; N.C. Ward; H.D. White; A.M. Wilson; I. Winship; A.M. Woodward; S.J. Nicholls; P. Brett; L. Elias; W. Malan; J. Irvin; K. Lambert; A. Pedrotti

doi:10.1016/j.ajpc.2021.100151

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Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective

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Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective

G.F. Watts, D.R. Sullivan, D.L. Hare, K.M. Kostner, A.E. Horton, D.A. Bell, T. Brett, R.J. Trent, N.K. Poplawski, A.C. Martin, …

American Journal of Preventive Cardiology, Vol.6, Art. 100151

2021

DOI: https://doi.org/10.1016/j.ajpc.2021.100151

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Abstract

Introduction Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease, with significant potential for positive impact on public health and healthcare savings. New clinical practice recommendations are presented in an abridged guidance to assist practitioners in enhancing the care of all patients with FH. Main recommendations Core recommendations are made on the detection, diagnosis, assessment and management of adults, children and adolescents with FH. There is a key role for general practitioners (GPs) working in collaboration with specialists with expertise in lipidology. Advice is given on genetic and cholesterol testing and risk notification of biological relatives undergoing cascade testing for FH; all healthcare professionals should develop skills in genomic medicine. Management is under-pinned by the precepts of risk stratification, adherence to healthy lifestyles, treatment of non-cholesterol risk factors, and appropriate use of low-density lipoprotein (LDL)-cholesterol lowering therapies, including statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. Recommendations on service design are provided in the full guidance. Potential impact on care of FH These recommendations need to be utilised using judicious clinical judgement and shared decision making with patients and families. Models of care need to be adapted to both local and regional needs and resources. In Australia new government funded schemes for genetic testing and use of PCSK9 inhibitors, as well as the National Health Genomics Policy Framework, will enable adoption of these recommendations. A broad implementation science strategy is, however, required to ensure that the guidance translates into benefit for all families with FH.

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Title: Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective
Authors/Creators: G.F. Watts (Author/Creator) - The University of Western Australia
D.R. Sullivan (Author/Creator) - The University of Sydney
D.L. Hare (Author/Creator) - The University of Melbourne
K.M. Kostner (Author/Creator) - The University of Queensland
A.E. Horton (Author/Creator) - Monash University
D.A. Bell (Author/Creator)
T. Brett (Author/Creator) - The University of Notre Dame Australia
R.J. Trent (Author/Creator) - The University of Sydney
N.K. Poplawski (Author/Creator) - The University of Adelaide
A.C. Martin (Author/Creator)
S. Srinivasan (Author/Creator) - The University of Sydney
R.N. Justo (Author/Creator) - The University of Queensland
C.K. Chow (Author/Creator) - The University of Sydney
J. Pang (Author/Creator) - The University of Western Australia
Z. Ademi (Author/Creator) - Monash University
J.J. Ardill (Author/Creator) - The University of Melbourne
W. Barnett (Author/Creator) - The University of Melbourne
T.R Bates (Author/Creator) - The University of Melbourne
L.J. Beilin (Author/Creator) - The University of Melbourne
W. Bishop (Author/Creator) - The University of Melbourne
J.A. Black (Author/Creator) - Menzies Research Institute
A. Brown (Author/Creator) - The University of Adelaide
J.R. Burnett (Author/Creator) - The University of Melbourne
C.A. Bursill (Author/Creator) - The University of Adelaide
A. Colley (Author/Creator) - The University of Melbourne
P.M. Clifton (Author/Creator) - The University of Melbourne
E.I. Ekinci (Author/Creator) - The University of Melbourne
G.A. Figtree (Author/Creator) - The University of Melbourne
B.H. Forge (Author/Creator) - The University of Melbourne
J. Garton-Smith (Author/Creator) - The University of Melbourne
D.F. Graham (Author/Creator) - The University of Melbourne
I. Hamilton-Craig (Author/Creator) - The University of Melbourne
C.R. Hamilton-Craig (Author/Creator) - The University of Queensland
C. Heal (Author/Creator) - James Cook University
C.M. Hespe (Author/Creator) - University of Notre Dame
A.J. Hooper (Author/Creator) - The University of Melbourne
L.G. Howes (Author/Creator) - The University of Melbourne
J. Ingles (Author/Creator) - The University of Melbourne
E.D. Janus (Author/Creator) - The University of Melbourne
N. Kangaharan (Author/Creator) - The University of Melbourne
A.C. Keech (Author/Creator) - The University of Melbourne
A.B. Kirke (Author/Creator) - The University of Melbourne
L. Kritharides (Author/Creator) - The University of Sydney
C.V. Kyle (Author/Creator) - The University of Melbourne
P. Lacaze (Author/Creator) - Monash University
S.C.H. Li (Author/Creator) - The University of Melbourne
S. Maticevic (Author/Creator) - The University of Melbourne
B.M. McQuillan (Author/Creator) - The University of Melbourne
S. Mirzaee (Author/Creator) - The University of Melbourne
T.A. Mori (Author/Creator) - The University of Melbourne
A.C. Morton (Author/Creator) - The University of Melbourne
D.M. Colquhoun (Author/Creator) - The University of Queensland
J.C. Moullin (Author/Creator) - The University of Melbourne
P.J. Nestel (Author/Creator) - Baker Heart and Diabetes Institute
K.J. Nowak (Author/Creator) - The University of Melbourne
R.C. O'Brien (Author/Creator) - The University of Melbourne
N. Pachter (Author/Creator) - The University of Melbourne
M.M. Page (Author/Creator)
P.J. Psaltis (Author/Creator) - The University of Adelaide
J. Radford (Author/Creator) - University of Tasmania
N.J. Reid (Author/Creator) - The University of Melbourne
E.N. Robertson (Author/Creator) - The University of Melbourne
J.D.M. Ryan (Author/Creator) - The University of Melbourne
M.N. Sarkies (Author/Creator) - Macquarie University
C.J. Schultz (Author/Creator) - The University of Melbourne
R.S. Scott (Author/Creator) - The University of Melbourne
C. Semsarian (Author/Creator)
L.A. Simons (Author/Creator) - UNSW Sydney
C. Spinks (Author/Creator) - The University of Melbourne
A.M. Tonkin (Author/Creator) - Monash University
F. van Bockxmeer (Author/Creator) - The University of Melbourne
K.E. Waddell-Smith (Author/Creator) - The University of Melbourne
N.C. Ward (Author/Creator) - The University of Melbourne
H.D. White (Author/Creator) - The University of Melbourne
A.M. Wilson (Author/Creator) - The University of Melbourne
I. Winship (Author/Creator) - The University of Melbourne
A.M. Woodward (Author/Creator) - The University of Melbourne
S.J. Nicholls (Author/Creator) - Monash University
P. Brett (Author/Creator) - The University of Melbourne
L. Elias (Author/Creator) - The University of Melbourne
W. Malan (Author/Creator) - RMIT University
J. Irvin (Author/Creator) - The University of Melbourne
K. Lambert (Author/Creator) - Edith Cowan University
A. Pedrotti (Author/Creator) - The University of Melbourne
Publication Details: American Journal of Preventive Cardiology, Vol.6, Art. 100151
Publisher: Elsevier BV
Identifiers: 991005544908607891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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