Journal article
Synthesis and biological evaluation of triazolylnucleosides as antibacterial and anticancer agents
Chemical Data Collections, Vol.28, Art.100429
2020
Abstract
A series of novel triazolylnucleosides has been efficiently synthesized (6a-h, 7a-b) by azide–alkyne 1,3-dipolar cycloaddition reaction and evaluated for antibacterial and anticancer activities. These nucleosides (6a-h) were screened against Staphylococcus aureus (ATCC 6538), gram-positive and Escherichia coli (ATCC 10536), Salmonella and Pseudomonas gram-negative bacterial strains. Among the series, three compounds (6c-e) exhibited significant levels of antibacterial activity against Staphylococcus aureus in reference to the standard drug, Levofloxacin. Triazolylnucleosides (6a-h) were also screened for anti-proliferative activities against cancer cell lines such as Huh-7 liver cancer cells. Three compounds (6e, 7a-b) have displayed promising anti-proliferative activity against Huh-7 and U87G cancer cells lines.
Details
- Title
- Synthesis and biological evaluation of triazolylnucleosides as antibacterial and anticancer agents
- Authors/Creators
- . Ankit (Author/Creator)T. Wang (Author/Creator)R.N. Veedu (Author/Creator)F. Abdmouleh (Author/Creator)M.E. Arbi (Author/Creator)S. Kumar (Author/Creator)
- Publication Details
- Chemical Data Collections, Vol.28, Art.100429
- Publisher
- Elsevier B.V.
- Identifiers
- 991005540499607891
- Copyright
- © 2020 Elsevier B.V.
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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