Synthesis and physical properties of choline carboxylate ionic liquids

N. Muhammad; M.I. Hossain; Z. Man; M. El-Harbawi; M.A. Bustam; Y.A. Noaman; N.B. Mohamed Alitheen; M.K. Ng; G. Hefter; C-Y Yin

doi:10.1021/je300086w

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Synthesis and physical properties of choline carboxylate ionic liquids

Journal article

Peer reviewed

Synthesis and physical properties of choline carboxylate ionic liquids

N. Muhammad, M.I. Hossain, Z. Man, M. El-Harbawi, M.A. Bustam, Y.A. Noaman, N.B. Mohamed Alitheen, M.K. Ng, G. Hefter and C-Y Yin

Journal of Chemical & Engineering Data, Vol.57(8), pp.2191-2196

2012

DOI: https://doi.org/10.1021/je300086w

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Abstract

A series of choline carboxylate ionic liquids (ILs) have been synthesized by neutralization of choline hydroxide solution with acetic, propanoic, butanoic, pivalic, and hexanoic acids. The salts so obtained were characterized by NMR spectroscopy, thermal methods, and elemental analysis. Key physical properties (density, viscosity, and refractive index) were measured for the propanoate, butanoate, and hexanoate salts at temperatures from (293.15 to 353.15) K. The densities were used to estimate the molecular volumes, standard entropies, crystal lattice energies, and thermal expansion coefficients. All five choline carboxylates were found to have cytotoxicities (IC50 values) above 10 mM toward the human breast cancer cell line, MCF-7, indicating they are much less toxic than common imidazolium-based ILs.

Details

Title: Synthesis and physical properties of choline carboxylate ionic liquids
Authors/Creators: N. Muhammad (Author/Creator) - Universiti Teknologi Petronas
M.I. Hossain (Author/Creator)
Z. Man (Author/Creator) - Universiti Teknologi Petronas
M. El-Harbawi (Author/Creator) - Universiti Teknologi Petronas
M.A. Bustam (Author/Creator) - Universiti Teknologi Petronas
Y.A. Noaman (Author/Creator) - Universiti Putra Malaysia
N.B. Mohamed Alitheen (Author/Creator)
M.K. Ng (Author/Creator)
G. Hefter (Author/Creator) - Murdoch University
C-Y Yin (Author/Creator) - Murdoch University
Publication Details: Journal of Chemical & Engineering Data, Vol.57(8), pp.2191-2196
Publisher: American Chemical Society
Identifiers: 991005543392607891
Murdoch Affiliation: School of Chemical and Mathematical Science
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.89 Ionic, Molecular & Complex Liquids; 2.89.508 Ionic Liquids
Web Of Science research areas: Chemistry, Multidisciplinary; Engineering, Chemical; Thermodynamics
ESI research areas: Chemistry