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Synthesis of 2-acetyl-5,8-dimethoxytetralin - an important anthracyclinone intermediate
Journal article   Open access   Peer reviewed

Synthesis of 2-acetyl-5,8-dimethoxytetralin - an important anthracyclinone intermediate

R.G.F. Giles and I.R. Green
South African Journal of Chemistry, Vol.43(3-4), pp.87-90
1990
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Abstract

The important anthracyclinone intermediate, 2-acetyl-5,8-dimethoxytetralin, has been synthesized in five steps in an overall yield of 51 % starting from 5,8-dihydroxy-1 ,4-dihydronaphthalene. Since all the steps are straightforward the method lends itself to muhigram synthesis.

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