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Synthesis of a protected 2-ethoxy-3-hydroxyethylfuran and its regioselectivity as a Diels–Alder diene on reaction with 3,5-dimethoxydehydrobenzene
Journal article   Open access   Peer reviewed

Synthesis of a protected 2-ethoxy-3-hydroxyethylfuran and its regioselectivity as a Diels–Alder diene on reaction with 3,5-dimethoxydehydrobenzene

R.G.F. Giles and C.P. Taylor
Arkivoc, Vol.2002(3)
2002
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Abstract

As a potential route for the synthesis of naturally occurring benzisochromanequinones, 2-ethoxy-3-(1′-methoxymethoxyethyl)furan 15 was prepared and shown to react regioselectively with in situ generated 3,5-dimethoxydehydrobenzene to afford, after hydrolysis and alkylation, the target naphthalene 1-(6′,8′-dimethoxy-1′-ethoxy-4′- isopropoxy-2′-naphthalenyl)-1-(methoxymethoxy)ethane 27...

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Citation topics
1 Clinical & Life Sciences
1.219 Cancer Drugs
1.219.1527 Naphthoquinone Derivatives
Web Of Science research areas
Chemistry, Organic
ESI research areas
Chemistry
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