Journal article
Systemic long-term metabolic effects of acute non-severe paediatric burn injury
Scientific Reports, Vol.12(1), Art. 13043
2022
Abstract
A growing body of evidence supports the concept of a systemic response to non-severe thermal trauma. This provokes an immunosuppressed state that predisposes paediatric patients to poor recovery and increased risk of secondary morbidity. In this study, to understand the long-term systemic effects of non-severe burns in children, targeted mass spectrometry assays for biogenic amines and tryptophan metabolites were performed on plasma collected from child burn patients at least three years post injury and compared to age and sex matched non-burn (healthy) controls. A panel of 12 metabolites, including urea cycle intermediates, aromatic amino acids and quinolinic acid were present in significantly higher concentrations in children with previous burn injury. Correlation analysis of metabolite levels to previously measured cytokine levels indicated the presence of multiple cytokine-metabolite associations in the burn injury participants that were absent from the healthy controls. These data suggest that there is a sustained immunometabolic imprint of non-severe burn trauma, potentially linked to long-term immune changes that may contribute to the poor long-term health outcomes observed in children after burn injury.
Details
- Title
- Systemic long-term metabolic effects of acute non-severe paediatric burn injury
- Authors/Creators
- S. Begum (Author/Creator)B.Z. Johnson (Author/Creator)A-C Morillon (Author/Creator)R. Yang (Author/Creator)S-H Bong (Author/Creator)L. Whiley (Author/Creator)N. Gray (Author/Creator)V.S. Fear (Author/Creator)L. Cuttle (Author/Creator)A.J.A. Holland (Author/Creator)J.K. Nicholson (Author/Creator)F.M. Wood (Author/Creator)M.W. Fear (Author/Creator)E. Holmes (Author/Creator)
- Publication Details
- Scientific Reports, Vol.12(1), Art. 13043
- Publisher
- Springer Nature
- Identifiers
- 991005543697007891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- Australian National Phenome Centre; Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.266 Wounds & Ulcers
- 1.266.1023 Burns
- Web Of Science research areas
- Surgery
- ESI research areas
- Clinical Medicine