Journal article
Systemic use of pentosan polysulphate in the treatment of osteoarthritis
Journal of Small Animal Practice, Vol.37(3), pp.108-114
1996
Abstract
Forty dogs diagnosed as having chronic osteoarthritis took part in a double-blind clinical dose-response study using the antiarthritic agent pentosan polysulphate (PPS). After complete physical examination to ensure good general health, dogs received four subcutaneous injections at intervals of one week of 0, 1, 3 or 5 mg/kg PPS from code-numbered bottles. At weekly intervals and four weeks after the last injection, weakness, stiffness, pain on joint manipulation, willingness to exercise, body condition and overall response were scored. There were no differences between groups in baseline data, but dogs receiving PPS had a favourable response compared to dogs receiving a placebo for lameness, body condition, pain on joint manipulation and willingness to exercise. The 3 mg/kg dose rate gave the best improvement, the 1 mg/kg dose was partially effective and the 5 mg/kg group was least effective. The use of PPS at a dose rate of 3 mg/kg for the treatment of clinical osteoarthritis in dogs is indicated by our study.
Details
- Title
- Systemic use of pentosan polysulphate in the treatment of osteoarthritis
- Authors/Creators
- R.A. Read (Author/Creator) - Murdoch UniversityD. Cullis-Hill (Author/Creator) - *Biopharm Australia, 111 Bronte Road, Bondi Junction, NSW 2022M.P. Jones (Author/Creator) - Macquarie University
- Publication Details
- Journal of Small Animal Practice, Vol.37(3), pp.108-114
- Publisher
- Blackwell Publishing
- Identifiers
- 991005545354007891
- Murdoch Affiliation
- School of Veterinary Studies
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.34 Orthopedics
- 1.34.255 Osteoarthritis
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science