Logo image
Back
Systemic use of pentosan polysulphate in the treatment of osteoarthritis
Journal article   Peer reviewed

Systemic use of pentosan polysulphate in the treatment of osteoarthritis

R.A. Read, D. Cullis-Hill and M.P. Jones
Journal of Small Animal Practice, Vol.37(3), pp.108-114
1996
DOI: https://doi.org/10.1111/j.1748-5827.1996.tb02355.x
url
Link to Published Version *Subscription may be requiredView

Abstract

Forty dogs diagnosed as having chronic osteoarthritis took part in a double-blind clinical dose-response study using the antiarthritic agent pentosan polysulphate (PPS). After complete physical examination to ensure good general health, dogs received four subcutaneous injections at intervals of one week of 0, 1, 3 or 5 mg/kg PPS from code-numbered bottles. At weekly intervals and four weeks after the last injection, weakness, stiffness, pain on joint manipulation, willingness to exercise, body condition and overall response were scored. There were no differences between groups in baseline data, but dogs receiving PPS had a favourable response compared to dogs receiving a placebo for lameness, body condition, pain on joint manipulation and willingness to exercise. The 3 mg/kg dose rate gave the best improvement, the 1 mg/kg dose was partially effective and the 5 mg/kg group was least effective. The use of PPS at a dose rate of 3 mg/kg for the treatment of clinical osteoarthritis in dogs is indicated by our study.

Details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Metrics

44 Record Views
45 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.34 Orthopedics
1.34.255 Osteoarthritis
Web Of Science research areas
Veterinary Sciences
ESI research areas
Plant & Animal Science
Logo image