Systems Approach to Investigate the Role of Fruit and Vegetable Types on Vascular Function in Pre-Hypertensive Participants: Protocol and Baseline Characteristics of a Randomised Crossover Dietary Intervention

Linda M. Oude Griep; Gary Frost; Elaine Holmes; Nicholas J. Wareham; Paul Elliott

doi:10.3390/nu16172923

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Systems Approach to Investigate the Role of Fruit and Vegetable Types on Vascular Function in Pre-Hypertensive Participants: Protocol and Baseline Characteristics of a Randomised Crossover Dietary Intervention

Journal article

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Systems Approach to Investigate the Role of Fruit and Vegetable Types on Vascular Function in Pre-Hypertensive Participants: Protocol and Baseline Characteristics of a Randomised Crossover Dietary Intervention

Linda M. Oude Griep, Gary Frost, Elaine Holmes, Nicholas J. Wareham and Paul Elliott

Nutrients, Vol.16(17), 2923

2024

DOI: https://doi.org/10.3390/nu16172923

PMID: 39275238

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Abstract

Life Sciences & Biomedicine

Nutrition & Dietetics

Science & Technology

The evidence on the impact of fruits and vegetable types on cardiovascular risk factors remains limited. Specifically, the utilisation of biomarkers to objectively measure dietary compliance and metabolic responses is emerging. This protocol and baseline characteristics of a pilot randomised controlled, crossover, dietary intervention study aimed to examine the effects of citrus fruits, cruciferous vegetables, or common fruits and vegetables on cardiovascular risk factors. A total of 39 volunteers with untreated prehypertension was recruited and consumed a standardised, provided diet with eight daily portions of citrus fruits and cruciferous vegetables, common fruits and vegetables, or a low fruit and vegetable diet (two portions/d, control diet) in a random order for 2 weeks each, separated by a wash-out week. A targeted cohort-based recruitment strategy was utilised and resulted in 74% of participants recruited by re-contacting preselected individuals from two cohort studies with a 15% average enrolment rate. Participants had an average age of 54.4 years (+/- 6.1 years), BMI of 27.9 kg/m(2), and BP of 135/81 mmHg and were mainly male (67%). The primary outcome was office blood pressure; secondary outcomes included arterial stiffness, lipid profiles, inflammation, cognitive function, and subjective mood. Biofluids, i.e., 24 h urine, stool, and blood samples, were collected for biomarker measurements with multiple metabolomic platforms and the gut microbial composition, together with traditional dietary biomarkers.

Details

Title: Systems Approach to Investigate the Role of Fruit and Vegetable Types on Vascular Function in Pre-Hypertensive Participants: Protocol and Baseline Characteristics of a Randomised Crossover Dietary Intervention
Authors/Creators: Linda M. Oude Griep - MRC Epidemiology Unit
Gary Frost - Hammersmith Hospital
Elaine Holmes - Murdoch University, Centre for Computational and Systems Medicine
Nicholas J. Wareham - MRC Epidemiology Unit
Paul Elliott - Imperial College London
Publication Details: Nutrients, Vol.16(17), 2923
Publisher: MDPI
Number of pages: 16
Grant note: Cambridge Epidemiology & Trials Unit, Cambridge Imperial College Research Fellowship SBF003\1101 / Springboard award from the Academy of Medical Sciences NIHR Imperial Clinical Research Facility, London NIHR203312 / UK NIHR Biomedical Research Centre Cambridge
Identifiers: 991005703764207891
Murdoch Affiliation: Centre for Computational and Systems Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.44 Nutrition & Dietetics; 1.44.29 Nutrition and Obesity
Web Of Science research areas: Nutrition & Dietetics
ESI research areas: Agricultural Sciences