Journal article
T Cell–Mediated hypersensitivity reactions to drugs
Annual Review of Medicine, Vol.66(1), pp.439-454
2015
Abstract
The immunological mechanisms driving delayed hypersensitivity reactions (HSRs) to drugs mediated by drug-reactive T lymphocytes are exemplified by several key examples and their human leukocyte antigen (HLA) associations: abacavir and HLA-B*57:01, carbamazepine and HLA-B*15:02, allo-purinol and HLA-B*58:01, and both amoxicillin-clavulanate and nevirapine with multiple class I and II alleles. For HLA-restricted drug HSRs, specific class I and/or II HLA alleles are necessary but not sufficient for tissue specificity and the clinical syndrome. Several models have been proposed to explain the immunopathogenesis of severe T cell–mediated drug HSRs, and our increased understanding of the risk factors and mechanisms involved in the development of these reactions will further the development of sensitive and specific strategies for preclinical screening that will lead to safer and more cost-effective drug design.
Details
- Title
- T Cell–Mediated hypersensitivity reactions to drugs
- Authors/Creators
- R. Pavlos (Author/Creator) - Murdoch UniversityS. Mallal (Author/Creator) - email: e.phillips@iiid.com.au.D. Ostrov (Author/Creator)S. Buus (Author/Creator)I. Metushi (Author/Creator)B. Peters (Author/Creator)E. Phillips (Author/Creator)
- Publication Details
- Annual Review of Medicine, Vol.66(1), pp.439-454
- Publisher
- Annual Reviews
- Identifiers
- 991005540539707891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Medicine, Research & Experimental
- ESI research areas
- Clinical Medicine