T cells from patients with Parkinson’s disease recognize α-synuclein peptides

D. Sulzer; R.N. Alcalay; F. Garretti; L. Cote; E. Kanter; J. Agin-Liebes; C. Liong; C. McMurtrey; W.H. Hildebrand; X. Mao; V.L. Dawson; T.M. Dawson; C. Oseroff; J. Pham; J. Sidney; M.B. Dillon; C. Carpenter; D. Weiskopf; E. Phillips; S. Mallal; B. Peters; A. Frazier; C.S. Lindestam Arlehamn; A. Sette

doi:10.1038/nature22815

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T cells from patients with Parkinson’s disease recognize α-synuclein peptides

Journal article

Peer reviewed

T cells from patients with Parkinson’s disease recognize α-synuclein peptides

D. Sulzer, R.N. Alcalay, F. Garretti, L. Cote, E. Kanter, J. Agin-Liebes, C. Liong, C. McMurtrey, W.H. Hildebrand, X. Mao, …

Nature, Vol.546(7660), pp.656-661

2017

DOI: https://doi.org/10.1038/nature22815

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Abstract

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

Details

Title: T cells from patients with Parkinson’s disease recognize α-synuclein peptides
Authors/Creators: D. Sulzer (Author/Creator)
R.N. Alcalay (Author/Creator)
F. Garretti (Author/Creator)
L. Cote (Author/Creator)
E. Kanter (Author/Creator)
J. Agin-Liebes (Author/Creator)
C. Liong (Author/Creator)
C. McMurtrey (Author/Creator)
W.H. Hildebrand (Author/Creator)
X. Mao (Author/Creator)
V.L. Dawson (Author/Creator)
T.M. Dawson (Author/Creator)
C. Oseroff (Author/Creator)
J. Pham (Author/Creator)
J. Sidney (Author/Creator)
M.B. Dillon (Author/Creator)
C. Carpenter (Author/Creator)
D. Weiskopf (Author/Creator)
E. Phillips (Author/Creator)
S. Mallal (Author/Creator)
B. Peters (Author/Creator)
A. Frazier (Author/Creator)
C.S. Lindestam Arlehamn (Author/Creator)
A. Sette (Author/Creator)
Publication Details: Nature, Vol.546(7660), pp.656-661
Publisher: Nature Publishing Group
Identifiers: 991005543627407891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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661 Times Cited - Web of Science

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Highly Cited Paper

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.67 Parkinson's Disease
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior