Journal article
TCR cross-reactivity and allorecognition: New insights into the immunogenetics of allorecognition
Immunogenetics, Vol.64(2), pp.77-85
2012
Abstract
Alloreactive T cells are core mediators of graft rejection and are a potent barrier to transplantation tolerance. It was previously unclear how T cells educated in the recipient thymus could recognize allogeneic HLA molecules. Recently it was shown that both naïve and memory CD4+ and CD8+ T cells are frequently cross-reactive against allogeneic HLA molecules and that this allorecognition exhibits exquisite peptide and HLA specificity and is dependent on both public and private specificities of the T cell receptor. In this review we highlight new insights gained into the immunogenetics of allorecognition, with particular emphasis on how viral infection and vaccination may specifically activate allo-HLA reactive T cells. We also briefly discuss the potential for virus-specific T cell infusions to produce GvHD. The progress made in understanding the molecular basis of allograft rejection will hopefully be translated into improved allograft function and/or survival, and eventually tolerance induction.
Details
- Title
- TCR cross-reactivity and allorecognition: New insights into the immunogenetics of allorecognition
- Authors/Creators
- L.J. D’Orsogna (Author/Creator)D.L. Roelen (Author/Creator)I.I.N. Doxiadis (Author/Creator)F.H.J. Claas (Author/Creator)
- Publication Details
- Immunogenetics, Vol.64(2), pp.77-85
- Publisher
- Springer-Verlag
- Identifiers
- 991005541674307891
- Copyright
- © 2011 The Author(s)
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.127 T Cell Regulation
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Immunology