Journal article
TNF and IL-1β exposure increases airway narrowing but does not alter the bronchodilatory response to deep inspiration in airway segments
Respirology, Vol.21(6), pp.1041-1048
2016
Abstract
Background and objective: While chronic inflammation of the airway wall and the failure of deep inspiration (DI) to produce bronchodilation are both common to asthma, whether pro-inflammatory cytokines modulate the airway smooth muscle response to strain during DI is unknown. The primary aim of the study was to determine how an inflammatory environment (simulated by the use of pro-inflammatory cytokines) alters the bronchodilatory response to DI. Methods: We used whole porcine bronchial segments in vitro that were cultured in medium containing tumour necrosis factor and interleukin-1β for 2days. A custom-built servo-controlled syringe pump and pressure transducer was used to measure airway narrowing and to simulate tidal breathing with intermittent DI manoeuvres. Results: Culture with tumour necrosis factor and interleukin-1β increased airway narrowing to acetylcholine but did not affect the bronchodilatory response to DI. Conclusion: The failure of DI to produce bronchodilation in patients with asthma may not necessarily involve a direct effect of pro-inflammatory cytokines on airway tissue. A relationship between inflammation and airway hyper-responsiveness is supported, however, regulated by separate disease processes than those which attenuate or abolish the bronchodilatory response to DI in patients with asthma.
Details
- Title
- TNF and IL-1β exposure increases airway narrowing but does not alter the bronchodilatory response to deep inspiration in airway segments
- Authors/Creators
- T.K. Ansell (Author/Creator)H.W. Mitchell (Author/Creator)P.K. McFawn (Author/Creator)P.B. Noble (Author/Creator)
- Publication Details
- Respirology, Vol.21(6), pp.1041-1048
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005544259407891
- Copyright
- © 2016 Asian Pacific Society of Respirology.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.65 Allergy
- 1.65.44 Asthma
- Web Of Science research areas
- Respiratory System
- ESI research areas
- Clinical Medicine