Journal article
Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma
Oncotarget, Vol.8(44), pp.78193-78207
2017
Abstract
Malignant mesothelioma is an aggressive and often fatal cancer associated with asbestos exposure. The disease originates in the mesothelial lining of the serosal cavities, most commonly affecting the pleura. Survival rates are low as diagnosis often occurs at an advanced stage and current treatments are limited. Identifying new diagnostic and therapeutic targets for mesothelioma remains a priority, particularly for the new wave of victims exposed to asbestos through do-it-yourself renovations and in countries where asbestos is still mined and used. Recent advances have demonstrated a biological role for the small but powerful gene regulators microRNA (miRNA) in mesothelioma. A number of potential therapeutic targets have been identified. MiRNA have also become popular as potential biomarkers for mesothelioma due to their stable expression in bodily fluid and tissues. In this review, we highlight the current challenges associated with the diagnosis and treatment of mesothelioma and discuss how targeting miRNA may improve diagnostic, prognostic and therapeutic approaches.
Details
- Title
- Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma
- Authors/Creators
- K.A. Birnie (Author/Creator)C.M. Prêle (Author/Creator)P.J. Thompson (Author/Creator)B. Badrian (Author/Creator)S.E. Mutsaers (Author/Creator)
- Publication Details
- Oncotarget, Vol.8(44), pp.78193-78207
- Publisher
- Impact Journals
- Identifiers
- 991005544530207891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.297 Asbestos & Mesothelioma
- 1.297.780 Asbestos-Mesothelioma Link
- Web Of Science research areas
- Cell Biology
- Oncology
- ESI research areas
- Molecular Biology & Genetics