Journal article
Temperature dependence of the sodium pump is altered in the cerebral cortex of CCK2 receptor-deficient mice
Neurochemical Research, Vol.35(5), pp.688-692
2010
Abstract
Previously we have shown that the temperature dependence of the sodium pump (Na+,K+-ATPase) is altered under different neuropathological conditions. In this study we compared temperature dependence of the Na+,K+-ATPase in the fronto-parietal cortex of CCK2 receptor-deficient (homo- and heterozygous) and normal (wild-type) mice. The Arrhenius plot for Na+,K+-ATPase from wild-type brain is non-linear with a breakpoint at 20.3 ± 0.4°C. In case of the brain cell membrane of CCK2 receptor-deficient mice (homo- and heterozygous) the breakpoint on Arrhenius plot was detected at 26.0 ± 1.1°C and 25.4 ± 0.4°C, respectively. The shift of the breakpoint on the Arrhenius plot established in CCK2 receptor-deficiency as well as in case of some other pathological conditions confirms that such kind of alteration in the Na+,K+-ATPase temperature dependence is likely related to the homeostatic adjustment of altered function of the sodium pump.
Details
- Title
- Temperature dependence of the sodium pump is altered in the cerebral cortex of CCK2 receptor-deficient mice
- Authors/Creators
- T. Salum (Author/Creator)S. Kõks (Author/Creator)C. Kairane (Author/Creator)R. Mahlapuu (Author/Creator)M. Zilmer (Author/Creator)E. Vasar (Author/Creator)
- Publication Details
- Neurochemical Research, Vol.35(5), pp.688-692
- Publisher
- Springer US
- Identifiers
- 991005544943107891
- Copyright
- © 2010 Springer Science+Business Media, LLC
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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