Tertiary hypothyroidism in a dog

Robert E Shiel; E. Acke; A. Puggioni; J. P. Cassidy; C.T. Mooney

doi:10.1186/2046-0481-60-2-88

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Journal article

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Tertiary hypothyroidism in a dog

Robert E Shiel, E. Acke, A. Puggioni, J. P. Cassidy and C.T. Mooney

Irish veterinary journal, Vol.60(2), 88

2007

DOI: https://doi.org/10.1186/2046-0481-60-2-88

PMCID: PMC3113834

PMID: 21851691

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Abstract

A nine-year-old male entire Labrador was diagnosed with pituitary dependent hyperadrenocorticism. Following seven months of successful mitotane therapy, the dog presented with marked weight gain, seborrhoea and alopecia. Routine clinicopathological analyses revealed marked hypercholesterolaemia. Serum total and free thyroxine (T4) concentrations were below their respective reference ranges. Serum thyroid stimulating hormone (cTSH) concentration was within reference range. TSH and thyrotropin releasing hormone (TRH) response tests revealed adequate stimulation of total T4 in both, and cTSH in the latter test. Magnetic resonance imaging revealed a mass arising from the pituitary fossa, with suprasellar extension. A diagnosis of tertiary hypothyroidism was made. Following four weeks of levothyroxine therapy, circulating cholesterol concentration had declined, weight loss had ensued and dermatological abnormalities had improved. Euthanasia was performed four months later due to the development of neurological signs. A highly infiltrative pituitary adenoma, with effacement of the overlying hypothalamus was identified on post mortem examination. Tertiary hypothyroidism has not been previously reported in dogs.

Details

Title: Tertiary hypothyroidism in a dog
Authors/Creators: Robert E Shiel
E. Acke
A. Puggioni
J. P. Cassidy
C.T. Mooney - University College Dublin
Publication Details: Irish veterinary journal, Vol.60(2), 88
Publisher: BioMed Central Ltd as Part of Springer Nature.
Identifiers: 991005573170007891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.213 Thyroid Disorders; 1.213.168 Thyroid Disorders
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science