Journal article
Test Re-test reliability of Dual-site TMS measures of SMA-M1 connectivity differs across Inter-stimulus intervals in younger and older adults
Neuroscience, Vol.472, pp.11-24
2021
Abstract
Dual-site transcranial magnetic stimulation (TMS) is a promising tool to measure supplementary motor area and primary motor cortex (SMA-M1) connectivity in younger and older adults, and could be used to understand the pathophysiology of movement disorders. However, test re-test reliability of dual-site TMS measures of SMA-M1 connectivity has not been established. We examined the reliability of SMA-M1 connectivity using dual-site TMS in two sessions in 30 younger and 30 older adults. For dual-site TMS, a conditioning pulse delivered to SMA (140% of active motor threshold) preceded a test pulse delivered to M1 (intensity that elicited MEPs of ~1 mV) by inter-stimulus intervals (ISI) of 6 ms, 7 ms, and 8 ms. Moderate intraclass correlation coefficients (ICC) were found for SMA-M1 connectivity at an ISI of 7 ms in younger (ICC: 0.69) and older adults (ICC: 0.68). Poor ICCs were found for SMA-M1 connectivity at ISIs of 6 ms and 8 ms in both age groups (ICC range: 0.01–0.40). We report evidence for stable measures of SMA-M1 connectivity at an ISI of 7 ms in both age groups. These findings are foundational for future research developing evidence-based interventions to strengthen SMA-M1 connectivity to improve bilateral motor control in older adults and populations with movement disorders.
Details
- Title
- Test Re-test reliability of Dual-site TMS measures of SMA-M1 connectivity differs across Inter-stimulus intervals in younger and older adults
- Authors/Creators
- B.K. Rurak (Author/Creator) - Murdoch UniversityJ.P. Rodrigues (Author/Creator) - Hollywood Private HospitalB.D. Power (Author/Creator) - The University of Notre Dame AustraliaP.D. Drummond (Author/Creator) - Murdoch UniversityA.M. Vallence (Author/Creator) - Murdoch University
- Publication Details
- Neuroscience, Vol.472, pp.11-24
- Publisher
- Elsevier Ltd.
- Identifiers
- 991005544563907891
- Copyright
- © 2021 IBRO.
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics; Health Futures Institute
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior