Testing the efficacy of kitasamycin for use in the control and treatment of swine dysentery in experimentally infected pigs

T. La; N.D. Phillips; H. Dunlop; K. Lugsomya; F. Coiacetto; D.J. Hampson

doi:10.1111/avj.12876

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Testing the efficacy of kitasamycin for use in the control and treatment of swine dysentery in experimentally infected pigs

Journal article

Peer reviewed

Testing the efficacy of kitasamycin for use in the control and treatment of swine dysentery in experimentally infected pigs

T. La, N.D. Phillips, H. Dunlop, K. Lugsomya, F. Coiacetto and D.J. Hampson

Australian Veterinary Journal, Vol.97(11), pp.452-464

2019

DOI: https://doi.org/10.1111/avj.12876

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Abstract

Background Swine dysentery (SD) caused by Brachyspira hyodysenteriae is an important disease in Australia. Aim The aim of this study is to evaluate the macrolide antibiotic kitasamycin for use in SD control. Methods The minimum inhibitory concentrations (MICs) of kitasamycin, tylosin and lincomycin for 32 Australian isolates of B. hyodysenteriae were evaluated. Mutations in the 23S rRNA gene were examined. Isolate '13' with a low kitasamycin MIC was used to challenge weaner pigs. Sixty pigs were housed in 20 pens each containing three pigs: pigs in four pens received 2 kg/tonne of a product containing kitasamycin (3.1% active) prophylactically in their food starting 4 days before B. hyodysenteriae challenge (group 1); pigs in four pens were challenged and received the same dose therapeutically once one pig in a pen showed diarrhoea (group 2); four pens were challenged and received 4 kg/tonne of the product therapeutically (group 3); four pens were challenged but not medicated (group 4); two pens were unmedicated and unchallenged (group 5) and two pens received 2 kg/tonne and were unchallenged (group 6). Pigs were monitored for B. hyodysenteriae excretion and disease. Results Macrolide resistance was widespread, and mutations in the 23S rRNA gene were identified in 23 isolates. Four isolates with kitasamycin MICs < 5 μg/mL were considered susceptible. Following experimental challenge, 10 of 12 unmedicated pigs developed SD. No pigs receiving kitasamycin prophylactical or therapeutically developed SD. Medicated pigs shed low numbers of B. hyodysenteriae in their faeces. Conclusions Kitasamycin can help control SD in pigs infected with susceptible isolates of B. hyodysenteriae.

Details

Title: Testing the efficacy of kitasamycin for use in the control and treatment of swine dysentery in experimentally infected pigs
Authors/Creators: T. La (Author/Creator) - Murdoch University
N.D. Phillips (Author/Creator) - Murdoch University
H. Dunlop (Author/Creator) - Bendigo Health
K. Lugsomya (Author/Creator) - City University of Hong Kong
F. Coiacetto (Author/Creator) - Murdoch University, School of Veterinary Medicine
D.J. Hampson (Author/Creator) - City University of Hong Kong
Publication Details: Australian Veterinary Journal, Vol.97(11), pp.452-464
Publisher: Wiley-Blackwell
Identifiers: 991005541546707891
Copyright: © 2019 Australian Veterinary Association
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.248 Sexually Transmitted Infections; 1.248.2445 Lawsonia Intracellularis
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science