Texture-based classification of liver fibrosis using MRI

M.J. House; S.J. Bangma; M. Thomas; E.K. Gan; O.T. Ayonrinde; L.A. Adams; J.K. Olynyk; T.G. St Pierre

doi:10.1002/jmri.24536

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Texture-based classification of liver fibrosis using MRI

Journal article

Peer reviewed

Texture-based classification of liver fibrosis using MRI

M.J. House, S.J. Bangma, M. Thomas, E.K. Gan, O.T. Ayonrinde, L.A. Adams, J.K. Olynyk and T.G. St Pierre

Journal of Magnetic Resonance Imaging, Vol.41(2), pp.322-328

2015

DOI: https://doi.org/10.1002/jmri.24536

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Abstract

Purpose To investigate the ability of texture analysis of MRI images to stage liver fibrosis. Current noninvasive approaches for detecting liver fibrosis have limitations and cannot yet routinely replace biopsy for diagnosing significant fibrosis. Materials and Methods Forty-nine patients with a range of liver diseases and biopsy-confirmed fibrosis were enrolled in the study. For texture analysis all patients were scanned with a T2-weighted, high-resolution, spin echo sequence and Haralick texture features applied. The area under the receiver operating characteristics curve (AUROC) was used to assess the diagnostic performance of the texture analysis. Results The best mean AUROC achieved for separating mild from severe fibrosis was 0.81. The inclusion of age, liver fat and liver R2 variables into the generalized linear model improved AUROC values for all comparisons, with the F0 versus F1–4 comparison the highest (0.91). Conclusion Our results suggest that a combination of MRI measures, that include selected texture features from T2-weighted images, may be a useful tool for excluding fibrosis in patients with liver disease. However, texture analysis of MRI performs only modestly when applied to the classification of patients in the mild and intermediate fibrosis stages.

Details

Title: Texture-based classification of liver fibrosis using MRI
Authors/Creators: M.J. House (Author/Creator) - The University of Western Australia
S.J. Bangma (Author/Creator) - Resonance Health (Australia)
M. Thomas (Author/Creator) - Emphron Informatics Toowong Queensland Australia
E.K. Gan (Author/Creator) - Fremantle Hospital
O.T. Ayonrinde (Author/Creator) - The University of Western Australia
L.A. Adams (Author/Creator) - Sir Charles Gairdner Hospital
J.K. Olynyk (Author/Creator) - The University of Western Australia
T.G. St Pierre (Author/Creator)
Publication Details: Journal of Magnetic Resonance Imaging, Vol.41(2), pp.322-328
Publisher: Wiley
Identifiers: 991005542338207891
Copyright: © 2013 WILEY Periodicals, Inc.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.125 Hepatitis; 1.125.663 NAFLD
Web Of Science research areas: Radiology, Nuclear Medicine & Medical Imaging
ESI research areas: Clinical Medicine