The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial

Samantha L Gardener; Stephanie J Fuller; Sharon L Naismith; Laura Baker; Miia Kivipelto; Victor L Villemagne; Stuart M Grieve; Paul Yates; Stephanie R Rainey-Smith; Juliana Chen; Belinda Thompson; Nicola J Armstrong; Malika G Fernando; Carolina Blagojevic Castro; Silochna Meghwar; Rema Raman; Andrew Gleason; Catriona Ireland; Roger Clarnette; Kaarin J Anstey; Kevin Taddei; Manohar Garg; Hamid R Sohrabi; Ralph N Martins

doi:10.1002/trc2.12466

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The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial

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The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial

Samantha L Gardener, Stephanie J Fuller, Sharon L Naismith, Laura Baker, Miia Kivipelto, Victor L Villemagne, Stuart M Grieve, Paul Yates, Stephanie R Rainey-Smith, Juliana Chen, …

Alzheimer's & dementia : translational research & clinical interventions, Vol.10(2), e12466

2024

DOI: https://doi.org/10.1002/trc2.12466

PMID: 38596483

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Abstract

multidomain lifestyle intervention

dementia

study protocol

Australia

Alzheimer's disease

brain health

randomized controlled trial

Introduction The Finnish Geriatric Intervention Study (FINGER) led to the global dementia risk reduction initiative: World-Wide FINGERS (WW-FINGERS). As part of WW-FINGERS, the Australian AU-ARROW study mirrors aspects of FINGER, as well as US-POINTER. Method AU-ARROW is a randomized, single-blind, multisite, 2-year clinical trial (n = 600; aged 55–79). The multimodal lifestyle intervention group will engage in aerobic exercise, resistance training and stretching, dietary advice to encourage MIND diet adherence, BrainHQ cognitive training, and medical monitoring and health education. The Health Education and Coaching group will receive occasional health education sessions. The primary outcome measure is the change in a global composite cognitive score. Extra value will emanate from blood biomarker analysis, positron emission tomography (PET) imaging, brain magnetic resonance imaging (MRI), and retinal biomarker tests. Discussion The finalized AU-ARROW protocol is expected to allow development of an evidence-based innovative treatment plan to reduce cognitive decline and dementia risk, and effective transfer of research outcomes into Australian health policy. Highlights • Study protocol for a single-blind, randomized controlled trial, the AU-ARROW Study. • The AU-ARROW Study is a member of the World-Wide FINGERS (WW-FINGERS) initiative. • AU-ARROW's primary outcome measure is change in a global composite cognitive score. • Extra significance from amyloid PET imaging, brain MRI, and retinal biomarker tests. • Leading to development of an innovative treatment plan to reduce cognitive decline.

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Title: The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial
Authors/Creators: Samantha L Gardener - Edith Cowan University
Stephanie J Fuller - Macquarie University
Sharon L Naismith - The University of Sydney
Laura Baker - Wake Forest University
Miia Kivipelto - Karolinska Institutet
Victor L Villemagne - Edith Cowan University (Australia, Perth)
Stuart M Grieve - The University of Sydney
Paul Yates - Austin Health
Stephanie R Rainey-Smith - Murdoch University
Juliana Chen - Macquarie University
Belinda Thompson - Macquarie University
Nicola J Armstrong - Curtin University
Malika G Fernando - Macquarie University
Carolina Blagojevic Castro - Centre for Healthy Ageing Murdoch University Murdoch Western Australia Australia
Silochna Meghwar - Macquarie University
Rema Raman - University of Southern California
Andrew Gleason - Macquarie University
Catriona Ireland - The University of Sydney
Roger Clarnette - The University of Western Australia
Kaarin J Anstey - UNSW Sydney
Kevin Taddei - Edith Cowan University (Australia, Perth)
Manohar Garg - Macquarie University
Hamid R Sohrabi - Murdoch University
Ralph N Martins - Edith Cowan University (Australia, Perth)
Publication Details: Alzheimer's & dementia : translational research & clinical interventions, Vol.10(2), e12466
Publisher: Wiley Periodicals LLC on behalf of Alzheimer's Association.
Identifiers: 991005654243407891
Murdoch Affiliation: Centre for Healthy Ageing; School of Psychology
Language: English
Resource Type: Journal article

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