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Journal article
The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study
The journal of clinical endocrinology and metabolism, Vol.109(9), pp.e1697-e1707
2024
PMID: 38686701
Abstract
Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood.
Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk
of, or living with, T2D.
Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification
(DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D.
Results: Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong
independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that
incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes
cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with
a high intake of red meat and alcohol in people with diabetes.
Conclusion: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and
obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.
Details
- Title
- The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study
- Authors/Creators
- Rebeca Eriksen - Imperial College LondonMargaret C White - University of DundeeAdem Y Dawed - University of DundeeIsabel Garcia Perez - Imperial College LondonJoram M Posma - Imperial College LondonMark Haid - Helmholtz Zentrum MünchenSapna Sharma - Helmholtz Zentrum MünchenCornelia Prehn - Helmholtz Zentrum MünchenE Louise Thomas - University of WestminsterRobert W Koivula - Lund UniversityRoberto Bizzotto - National Research CouncilAndrea Mari - National Research CouncilGiuseppe N Giordano - Lund UniversityImre Pavo - , ,Jochen M Schwenk - Science for Life LaboratoryFederico De Masi - University of CopenhagenKonstantinos D Tsirigos - University of CopenhagenSøren Brunak - University of CopenhagenAna Viñuela - Newcastle UniversityAnubha Mahajan - Centre for Human GeneticsTimothy J McDonald - Royal Devon and Exeter HospitalTarja Kokkola - University of Eastern FinlandFemke Rutters - Amsterdam University Medical CentersJoline Beulens - , ,Mirthe Muilwijk - Amsterdam University Medical CentersMarieke Blom - Amsterdam University Medical CentersPetra Elders - , ,Tue H Hansen - University of CopenhagenJuan Fernandez-Tajes - Centre for Human GeneticsAngus Jones - Royal Devon and Exeter HospitalChris Jennison - University of BathMark Walker - Newcastle UniversityMark I McCarthy - Churchill HospitalOluf Pedersen - University of CopenhagenHartmut Ruetten - Sanofi (Germany)Ian Forgie - University of DundeeJens J Holst - University of CopenhagenHenrik S Thomsen - University of CopenhagenMartin Ridderstråle - Novo Nordisk FoundationJimmy D Bell - University of WestminsterJerzy Adamski - Duke-NUS Medical SchoolPaul W Franks - Harvard UniversityTorben Hansen - University of CopenhagenElaine Holmes - Imperial College LondonGary Frost - Imperial College LondonEwan R Pearson - University of DundeeFaculty of Medicine
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.109(9), pp.e1697-e1707
- Publisher
- Oxford University Press
- Grant note
- ; 115317 / ; NIHR-CDF-2017-10-032 / ; U01-DK105535 / ; FP7/2007-2013 / ; IRC15-0067; Dnr 349-2006-237 / ; 102820/Z/13/Z / ; 090532; 098381; 106130; 203141; 2122590 / ; Dnr 2009-1039 / ; NNF17OC0027594; NNF14CC0001 / ;
- Identifiers
- 991005884953407891
- Copyright
- © The Author(s) 2024
- Murdoch Affiliation
- Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
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