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CC BY V4.0, Open Access
Journal article
The Contribution of Rat Studies to Current Knowledge of Major Depressive Disorder: Results From Citation Analysis
Frontiers in Psychology, Vol.11, 1486
2020
Abstract
Major depressive disorder (MDD) is the most severe depression type and one of the leading causes of morbidity worldwide. Animal models are widely used to understand MDD etiology, pathogenesis, and treatment, but the efficacy of this research for patients has barely been systematically evaluated. Such evaluation is important given the resource consumption and ethical concerns incurred by animal use. We used the citation tracking facilities within Web of Science and Scopus to locate citations of original research papers on rats related to MDD published prior to 2013—to allow adequate time for citations—identified in PubMed and Scopus by relevant search terms. Resulting citations were thematically coded in eight categories, and descriptive statistics were calculated. 178 publications describing relevant rat studies were identified. They were cited 8,712 times. More than half (4,633) of their citations were by other animal studies. 794 (less than 10%) were by human medical papers. Citation analysis indicates that rat model research has contributed very little to the contemporary clinical understanding of MDD. This suggests a misuse of limited funding hence supporting a change in allocation of research and development funds targeting this disorder to maximise benefits for patients.
Details
- Title
- The Contribution of Rat Studies to Current Knowledge of Major Depressive Disorder: Results From Citation Analysis
- Authors/Creators
- Constanca Carvalho - University of LisbonFilipa Peste - University of AveiroTiago A Marques - University of LisbonAndrew Knight - University of WinchesterLuis M Vicente
- Publication Details
- Frontiers in Psychology, Vol.11, 1486
- Publisher
- Frontiers Media S.A.
- Identifiers
- 991005694751307891
- Copyright
- © 2020 Carvalho et al.
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.117 Pharmacology & Toxicology
- 1.117.2161 Non-Animal Testing
- Web Of Science research areas
- Psychology, Multidisciplinary
- ESI research areas
- Psychiatry/Psychology