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CC BY-NC-ND V4.0, Open Access
Journal article
The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure
JACC. Basic to translational science, Vol.9(6), pp.733-750
2024
PMID: 39070276
Abstract
Heart failure (HF) with left ventricular diastolic dysfunction is a growing global concern. This study evaluated myocardial oxidized nicotinamide adenine dinucleotide (NAD + ) levels in human systolic and diastolic HF and in a murine model of HF with preserved ejection fraction, exploring NAD + repletion as therapy. We quanti fied myocardial NAD + and nicotinamide phosphoribosyltransferase levels, assessing restoration with nicotinamide riboside (NR). Findings show signi ficant NAD + and nicotinamide phosphoribosyltransferase depletion in human diastolic HF myocardium, but NR successfully restored NAD + levels. In murine HF with preserved ejection fraction, NR as preventive and therapeutic intervention improved metabolic and antioxidant pro files. This study underscores NAD + repletion 's potential in diastolic HF management. (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
Details
- Title
- The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure
- Authors/Creators
- Yen Chin Koay - The University of SydneyRen Ping Liu - The University of SydneyBailey Mcintosh - The University of SydneyNiv Vigder - The University of SydneySerlin Lauren - The University of SydneyAngela Yu Bai - The University of SydneySaki Tomita - The University of SydneyDesmond Li - Natl Innovat Ctr, BCAL Diagnost, Eveleigh, NSW, AustraliaDylan Harney - The University of SydneyBenjamin Hunter - The University of SydneyYunwei ZhangJean Yang - The University of SydneyPaul Bannon - The University of SydneyAshleigh PhilipAndrew PhilipDavid M. Kaye - Monash UniversityMark Larance - The University of SydneySean Lal - The University of SydneyJohn F. O. Sullivan - The University of Sydney
- Publication Details
- JACC. Basic to translational science, Vol.9(6), pp.733-750
- Publisher
- Elsevier ON BEHALF OF THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION.
- Number of pages
- 18
- Grant note
- NSW Health Early-Mid Career Fellowship and Clinician-Scientist Awards: DOH1003, DOH1006 National Heart Foundation Future Leader Fellowship: NHF104853, NHF107180
This work was supported by the Sydney Medical School Foundation (Dr O 'Sullivan) ; Sydney Cardiovascular Fellowship (Dr O 'Sullivan) , NSW Health Early-Mid Career Fellowship and Clinician-Scientist Awards (Dr O 'Sullivan; DOH1003 and DOH1006) , National Heart Foundation Future Leader Fellowship (Dr O 'Sullivan; NHF104853) , National Heart Foundation Future Leader Fellowship (Dr Koay; NHF107180) , NSW Cardiovascular Collaborative Grant (Dr Koay) , and philanthropic support from The University of Sydney donors (Dr Lal) . All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Identifiers
- 991005707667607891
- Copyright
- © 2024 THE AUTHORS.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Web Of Science research areas
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- ESI research areas
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