Journal article
The Facial Evolution: Looking backward and moving forward
Human Mutation, Vol.34(1), pp.14-22
2012
Abstract
Three-dimensional (3D) facial analysis is ideal for high-resolution, nonionizing, noninvasive objective, high-throughput phenotypic, and phenomic studies. It is a natural complement to (epi)genetic technologies to facilitate advances in the understanding of rare and common diseases. The face is uniquely reflective of the primordial tissues, and there is evidence supporting the application of 3D facial analysis to the investigation of variation and disease including studies showing that the face can reflect systemic health, provides diagnostic clues to disorders, and that facial variation reflects biological pathways. In addition, facial variation has been related to evolutionary factors. The purpose of this review is to look backward to suggest that knowledge of human evolution supports, and may instruct, the application and interpretation of studies of facial morphology for documentation of human variation and investigation of its relationships with health and disease. Furthermore, in the context of advances of deep phenotyping and data integration, to look forward to suggest approaches to scalable implementation of facial analysis, and to suggest avenues for future research and clinical application of this technology.
Details
- Title
- The Facial Evolution: Looking backward and moving forward
- Authors/Creators
- G. Baynam (Author/Creator) - The University of Western AustraliaM. Walters (Author/Creator) - Princess Margaret Hospital for ChildrenP. Claes (Author/Creator) - KU LeuvenS. Kung (Author/Creator) - The University of Western AustraliaP. LeSouef (Author/Creator) - The University of Western AustraliaH. Dawkins (Author/Creator) - Curtin UniversityD. Gillett (Author/Creator) - Princess Margaret Hospital for ChildrenJ. Goldblatt (Author/Creator) - The University of Western Australia
- Publication Details
- Human Mutation, Vol.34(1), pp.14-22
- Publisher
- John Wiley & Sons Inc.
- Identifiers
- 991005544499207891
- Copyright
- © 2012 Wiley Periodicals, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
- Note
- Wiley video abstract attached
- Publisher URL
- https://www.youtube.com/watch?v=yEP7ExI-whw
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.54 Molecular & Cell Biology - Genetics
- 1.54.79 Genomic Bioinformatics
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics