Journal article
The International development of PROQOL-HCV: An instrument to assess the health-related quality of life of patients treated for Hepatitis C virus
BMC Infectious Diseases, Vol.16(1)
2016
Abstract
Background
Hepatitis C virus (HCV) compromises Health-related Quality of Life (HRQL) with detriments to Physical, Mental and Social health domains. Treatment with interferon and ribavirin is associated with side effects which further impair HRQL. New treatments appear potent, effective and tolerable. However, Patient Reported Outcomes instruments that capture the impact on HRQL for people with hepatitis C are largely non-specific and will be needed in the new treatment era. Therefore, we developed a conceptually valid multidimensional model of HCV-specific quality of life and pilot survey instrument, the Patient Reported Outcome Quality of Life survey for HCV (PROQOL-HCV).
Methods
HCV patients from France (n = 30), Brazil (n = 20) and Australia (n = 20) were interviewed to investigate HCV-HRQL issues raised in the scientific literature and by treatment specialists. Interviews were recorded, transcribed and translated into English and French.
Results
Fifteen content dimensions were derived from the qualitative analysis, refined and fitted to four domains: (1) Physical Health included: fatigue, pain, sleep, sexual impairment and physical activity; (2) Mental Health: psychological distress, psychosocial impact, and cognition; (3) Social Health: support, stigma, social activity, substance use; (4) Treatment: management, side effects, and fear of treatment failure. The impact of some dimensions extended beyond their primary domain including: physical activity, cognition, sleep, sexual impairment, and the three treatment dimensions. A bank of 300 items was constructed to reflect patient reports and, following expert review, reduced to a 72-item pilot questionnaire.
Conclusion
We present a conceptually valid multidimensional model of HCV-specific quality of life and the pilot survey instrument, PROQOL-HCV. The model is widely inclusive of the experience of hepatitis C and the first to include the treatment dimension.
Details
- Title
- The International development of PROQOL-HCV: An instrument to assess the health-related quality of life of patients treated for Hepatitis C virus
- Authors/Creators
- A.R. Armstrong (Author/Creator) - Australian Institute of Family StudiesS.E. Herrmann (Author/Creator) - Murdoch UniversityO. Chassany (Author/Creator) - Délégation Paris 7C. Lalanne (Author/Creator) - Délégation Paris 7M.H. Da Silva (Author/Creator) - DST SystemsE. Galano (Author/Creator) - DST SystemsP.M. Carrieri (Author/Creator) - InsermV. Estellon (Author/Creator) - Délégation Paris 5P. Sogni (Author/Creator) - Hôpital CochinM. Duracinsky (Author/Creator) - Délégation Paris 7
- Publication Details
- BMC Infectious Diseases, Vol.16(1)
- Publisher
- BioMed Central
- Identifiers
- 991005542071407891
- Copyright
- © 2016 The Author(s).
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.83 HCV
- Web Of Science research areas
- Infectious Diseases
- ESI research areas
- Immunology