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Journal article
The MothersBabies Study, an Australian prospective cohort study analyzing the microbiome in the preconception and perinatal period to determine risk of adverse pregnancy, postpartum, and child-related health outcomes: Study Protocol
International Journal of Environmental Research and Public Health, Vol.20(18), 6736
2023
Abstract
The microbiome has emerged as a key determinant of human health and reproduction, with recent evidence suggesting a dysbiotic microbiome is implicated in adverse perinatal health outcomes. The existing research has been limited by the sample collection and timing, cohort design, sample design, and lack of data on the preconception microbiome. This prospective, longitudinal cohort study will recruit 2000 Australian women, in order to fully explore the role of the microbiome in the development of adverse perinatal outcomes. Participants are enrolled for a maximum of 7 years, from 1 year preconception, through to 5 years postpartum. Assessment occurs every three months until pregnancy occurs, then during Trimester 1 (5 + 0–12 + 6 weeks gestation), Trimester 2 (20 + 0–24 + 6 weeks gestation), Trimester 3 (32 + 0–36 + 6 weeks gestation), and postpartum at 1 week, 2 months, 6 months, and then annually from 1 to 5 years. At each assessment, maternal participants self-collect oral, skin, vaginal, urine, and stool samples. Oral, skin, urine, and stool samples will be collected from children. Blood samples will be obtained from maternal participants who can access a study collection center. The measurements taken will include anthropometric, blood pressure, heart rate, and serum hormonal and metabolic parameters. Validated self-report questionnaires will be administered to assess diet, physical activity, mental health, and child developmental milestones. Medications, medical, surgical, obstetric history, the impact of COVID-19, living environments, and pregnancy and child health outcomes will be recorded. Multiomic bioinformatic and statistical analyses will assess the association between participants who developed high-risk and low-risk pregnancies, adverse postnatal conditions, and/or childhood disease, and their microbiome for the different sample types.
Details
- Title
- The MothersBabies Study, an Australian prospective cohort study analyzing the microbiome in the preconception and perinatal period to determine risk of adverse pregnancy, postpartum, and child-related health outcomes: Study Protocol
- Authors/Creators
- Naomi Strout - Sutherland HospitalLana Pasic - Sutherland HospitalChloe Hicks - Sutherland HospitalXin-Yi Chua - Sutherland HospitalNiki Tashvighi - Sutherland HospitalPhoebe ButlerZhixin Liu - UNSW SydneyFatima El-AssaadElaine Holmes - University of LondonDaniella Susic - Sutherland HospitalKatherine Samaras - Garvan Institute of Medical ResearchMaria E. Craig - UNSW SydneyGregory K. Davis - St George HospitalAmanda Henry - St George HospitalWilliam L. Ledger - UNSW SydneyEmad M. El-Omar - Sutherland Hospital
- Publication Details
- International Journal of Environmental Research and Public Health, Vol.20(18), 6736
- Publisher
- MDPI AG
- Identifiers
- 991005608868907891
- Copyright
- © 2023 by the authors
- Murdoch Affiliation
- Australian National Phenome Centre; Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
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