Journal article
The Origin of Regenerating Mesothelium: A Historical Perspective
The International Journal of Artificial Organs, Vol.30(6), pp.484-494
2007
Abstract
Bichat first described the mesothelium in 1827 but despite its early discovery, it has only been in recent years that its importance both in health and disease has been realised. One area still poorly understood is that of the mechanisms regulating mesothelial repair. Mesothelial cells are derived from the mesoderm but express many epithelial characteristics. However, mesothelium does not heal in the same way as other epithelial-like cells. Epithelium heals by centripetal migration, with cells at the edge of the wound proliferating and migrating into the injured area. Hertzler in 1919 noted that both large and small peritoneal injuries healed within the same time frame, concluding that the mesothelium could not heal solely by centripetal migration. The exact mechanisms involved in mesothelial regeneration following injury are controversial with a number of proposals suggested to explain the origin of the regenerating cells. This review will examine these proposals and give some insights into the likely mechanisms involved.
Details
- Title
- The Origin of Regenerating Mesothelium: A Historical Perspective
- Authors/Creators
- S.E. Mutsaers (Author/Creator) - School of Medicine and PharmacologyC. Prêle (Author/Creator) - The Kids Research Institute AustraliaS.M. Lansley (Author/Creator) - School of Medicine and PharmacologyS.E. Herrick (Author/Creator) - University of Manchester
- Publication Details
- The International Journal of Artificial Organs, Vol.30(6), pp.484-494
- Publisher
- SAGE Publications
- Identifiers
- 991005540549507891
- Copyright
- © 2007 by SAGE Publications
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
28 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.216 Abdominal Surgery
- 1.216.1563 Intestinal Obstruction
- Web Of Science research areas
- Engineering, Biomedical
- Transplantation
- ESI research areas
- Clinical Medicine