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Journal article
The Pharmacokinetics of Δ9-Tetrahydrocannabinol in Sheep
Animals (Basel), Vol.14(22), 3328
2024
Abstract
The pharmacokinetics of Δ9-tetrahydrocannabinol (Δ9-THC) has not been established in ruminants. Pharmacokinetic knowledge is important given feeding industrial hemp biomass has been shown to result in tissue residues post feeding in sheep. Due to a lack of testing and available data, a ‘maximum’ concentration of Δ9-THC has not been currently set for foods of animal origin. Consequently, this study was designed to gain a better understanding of how ruminants process Δ9-THC. Eight Merino ewes were administered with two per os (PO) doses of 88.5 mg Δ9-THC/kg bodyweight (BW) 12 h apart. Blood samples were collected periodically post dosing to determine the pharmacokinetics of Δ9-THC and subcutaneous fat biopsies were taken to investigate the deposition and elimination of Δ9-THC from sheep. An elimination half-life of 31.40 ± 13.87 h was identified, with residues persisting in the subcutaneous fat for 28 d in five of the eight sheep, before decreasing below the limit of detection in all sheep by 91 d. These results support the prolonged presence of Δ9-THC residues previously identified. Thus, imposing a practical withholding period for ruminants involved in the food chain may not be possible, with further research required to investigate how iHemp biomass may be safely fed to ruminants.
Details
- Title
- The Pharmacokinetics of Δ9-Tetrahydrocannabinol in Sheep
- Authors/Creators
- Sarah A. Stevens - Charles Sturt UniversityScott H. Edwards - Charles Sturt UniversityGlenys K. Noble - Charles Sturt UniversityColin J. Scrivener - Charles Sturt UniversityGaye L. Krebs - Charles Sturt UniversityChristopher E. Petzel - Charles Sturt UniversityChristopher D. May - ChemCentreZi Xuan TaiBronwyn L. BlakeKenneth C. DodsLeon N. Warne - Murdoch University
- Publication Details
- Animals (Basel), Vol.14(22), 3328
- Publisher
- MDPI
- Identifiers
- 991005718555507891
- Copyright
- © 2024 by the authors
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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