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CC BY-NC-ND V4.0, Open Access
Journal article
The Pragmatic Removal of Penicillin Allergy Electronic Health Record Labels (PROPEL) Trial: A Randomized Clinical Trial
The journal of allergy and clinical immunology in practice (Cambridge, MA), Vol.13(10), pp.2747-2755
2025
PMID: 40675326
Abstract
Inaccurate penicillin allergy labels (PALs) affect antimicrobial stewardship, health outcomes, and costs. More than 95% of PALs can be de-labeled when tested, but this rarely happens.
We sought to determine whether education and an electronic health record (EHR) tool kit to identify low-risk PALs would facilitate inpatient penicillin allergy de-labeling by pharmacists.
Pragmatic Removal of Penicillin Allergy Electronic Health Record Labels was a stepped-wedge, nonblinded, randomized, controlled, pragmatic clinical trial including 12 inpatient medical units. From November 2020 to November 2021, units entered intervention at 1-month stepped intervals in random order. Medically stable, nonpregnant adults with an her-documented PAL who were hospitalized on intervention units for 24 hours were included. The intervention included pharmacist and nursing education, a patient list for systematic identification of PALs, presentation of a risk-assessment tool, and an oral amoxicillin challenge order set. The primary outcome was removal of PAL by hospital discharge. Secondary outcomes included safety and implementation measures, longer-term continued label removal, and antibiotic use.
On 12 randomized units, 2,052 patients with a PAL presented during the 1-year trial. More intervention-exposed patients had EHR-documented penicillin allergy removal compared with controls (45 of 1,018 [4.4%] vs 31 of 1,034 [3%], respectively; adjusted odds ratio = 2.05; 95% CI, 1.08-3.91). More intervention-exposed patients received an EHR-documented penicillin allergy risk assessment than did controls (86 of 1,018 [8.4%] vs 27 of 1,034 [2.6%]; adjusted odds ratio = 6.42; 95% CI, 3.08-13.38). Moreover, 27 of 1,018 intervention patients (2.7%) received amoxicillin challenge compared with 21 of 1,034 control patients (2.0%). All amoxicillin challenges were tolerated.
Education and deployment of an inpatient EHR tool kit increased the rate of inpatient removal of inaccurate penicillin allergies before discharge.
Details
- Title
- The Pragmatic Removal of Penicillin Allergy Electronic Health Record Labels (PROPEL) Trial: A Randomized Clinical Trial
- Authors/Creators
- Cosby A. Stone - Vanderbilt University Medical CenterHeather L. Prigmore - Vanderbilt University Medical CenterAllison B. McCoy - Vanderbilt University Medical CenterJoanna L. Stollings - Vanderbilt University Medical CenterMary Lynn Dear - Vanderbilt University Medical CenterWilliam Hiser - Vanderbilt University Medical CenterGrace Van Winkle - Vanderbilt University Medical CenterSunil Kripalani - Vanderbilt University Medical CenterAdam Wright - Vanderbilt University Medical CenterFrank E. Harrell - Vanderbilt University Medical CenterTodd W. Rice - Vanderbilt University Medical CenterChristopher J. Lindsell - Duke UniversityElizabeth J. Phillips - Vanderbilt UniversityVanderbilt Learning Healthcare System Platform Investigators
- Publication Details
- The journal of allergy and clinical immunology in practice (Cambridge, MA), Vol.13(10), pp.2747-2755
- Publisher
- Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
- Number of pages
- 9
- Grant note
- Agency for Healthcare Research and Quality
- Identifiers
- 991005831949407891
- Copyright
- © 2025 The Authors.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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