The Relationship between Diet, Depression, and Alzheimer’s Disease: A Narrative Review

Hilal Salim Said Al Shamsi; Stephanie Rainey-Smith; Samantha Gardener; Hamid Sohrabi; Rodrigo Canovas; Ralph Martins; Binosha Fernando

doi:10.1002/mnfr.202300419

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The Relationship between Diet, Depression, and Alzheimer’s Disease: A Narrative Review

Journal article

Open access

Peer reviewed

The Relationship between Diet, Depression, and Alzheimer’s Disease: A Narrative Review

Hilal Salim Said Al Shamsi, Stephanie Rainey-Smith, Samantha Gardener, Hamid Sohrabi, Rodrigo Canovas, Ralph Martins and Binosha Fernando

Molecular nutrition & food research, 2300419

2024

DOI: https://doi.org/10.1002/mnfr.202300419

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Abstract

Dementia

depression

Alzheimer's disease

Cognitive Decline

Diet

Psychology of ageing

Neurosciences

Other biomedical and clinical sciences

Purpose of Review: This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings: AD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, along with adherence to dietary patterns like the Mediterranean diet, which includes multiple beneficial dietary factors. Summary: The investigation of dietary factors in the prevention of depression and AD is a comparatively young field of research. Comprehensive highly characterised longitudinal datasets and advanced analytical approaches are required to further examine the complex relationship between diet, depression, and AD. There is a critical need for more research in this area to develop effective preventive strategies aimed at maintaining mental and physical health with advancing age.

Details

Title: The Relationship between Diet, Depression, and Alzheimer’s Disease: A Narrative Review
Authors/Creators: Hilal Salim Said Al Shamsi (Author) - Edith Cowan University
Stephanie Rainey-Smith (Author) - Murdoch University, Centre for Healthy Ageing
Samantha Gardener (Author) - Edith Cowan University
Hamid Sohrabi (Author) - Murdoch University, Centre for Healthy Ageing
Rodrigo Canovas (Author)
Ralph Martins (Author)
Binosha Fernando (Corresponding Author)
Publication Details: Molecular nutrition & food research, 2300419
Publisher: Molecular Nutrition & Food Research published by Wiley-VCH GmbH
Identifiers: 991005684570307891
Murdoch Affiliation: Centre for Healthy Ageing; School of Psychology
Language: English
Resource Type: Journal article

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