The Relevance of In Silico, In Vitro and Non-human Primate Based Approaches to Clinical Research on Major Depressive Disorder

Constança Carvalho; Susana A M Varela; Luísa Ferreira Bastos; Inês Orfão; Vanda Beja; Manuel Sapage; Tiago A Marques; Andrew Knight; Luís Vicente

doi:10.1177/0261192919885578

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The Relevance of In Silico, In Vitro and Non-human Primate Based Approaches to Clinical Research on Major Depressive Disorder

Journal article

Open access

Peer reviewed

The Relevance of In Silico, In Vitro and Non-human Primate Based Approaches to Clinical Research on Major Depressive Disorder

Constança Carvalho, Susana A M Varela, Luísa Ferreira Bastos, Inês Orfão, Vanda Beja, Manuel Sapage, Tiago A Marques, Andrew Knight and Luís Vicente

Alternatives to laboratory animals, Vol.47(3-4), pp.128-139

2019

DOI: https://doi.org/10.1177/0261192919885578

PMID: 31838868

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Abstract

Animals

Computer Simulation

Depressive Disorder, Major

Disease Models, Animal

Humans

In Vitro Techniques

Primates

Research Design - standards

Research Design - trends

Major depressive disorder (MDD) is the most severe form of depression and the leading cause of disability worldwide. When considering research approaches aimed at understanding MDD, it is important that their effectiveness is evaluated. Here, we assessed the effectiveness of original studies on MDD by rating their contributions to subsequent medical papers on the subject, and we compared the respective contribution of findings from non-human primate (NHP) studies and from human-based or research approaches. For each publication, we conducted a quantitative citation analysis and a systematic qualitative analysis of the citations. In the majority of cases, human-based research approaches (both and ) received more citations in subsequent human research papers than did NHP studies. In addition, the human-based approaches were considered to be more relevant to the hypotheses and/or to the methods featured in the citing papers. The results of this study suggest that studies based on and approaches are taken into account by medical researchers more often than are NHP-based approaches. In addition, these human-based approaches are usually cheaper and less ethically contentious than NHP studies. Therefore, we suggest that the traditional animal-based approach for testing medical hypotheses should be revised, and more opportunities created for further developing human-relevant innovative techniques.

Details

Title: The Relevance of In Silico, In Vitro and Non-human Primate Based Approaches to Clinical Research on Major Depressive Disorder
Authors/Creators: Constança Carvalho - University of Lisbon
Susana A M Varela - University of Lisbon
Luísa Ferreira Bastos - Institute of Mechanical Engineering and Industrial Mangement
Inês Orfão - University of Lisbon
Vanda Beja - Independent Consultant, Clinical Psychologist, Lisboa, Portugal
Manuel Sapage - University of Lisbon
Tiago A Marques - University of St Andrews
Andrew Knight - University of Winchester
Luís Vicente - University of Lisbon
Publication Details: Alternatives to laboratory animals, Vol.47(3-4), pp.128-139
Publisher: SAGE Publications
Identifiers: 991005694751507891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.117 Pharmacology & Toxicology; 1.117.2161 Non-Animal Testing
Web Of Science research areas: Medicine, Research & Experimental
ESI research areas: Plant & Animal Science