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Published (Version of Record)CC BY V4.0, Open Access
Journal article
The Role of Diet and Gut Microbiota in Alzheimer's Disease
Nutrients, Vol.16(3), 412
2024
PMCID: PMC10857293
PMID: 38337696
Abstract
Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau tangles. Currently, Alzheimer’s disease (AD) impacts 50 million individuals, with projections anticipating an increase to 152 million by the year 2050. Despite the increasing global prevalence of AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis and treatment. Recent research suggests a link between gut dysbiosis and the aggregation of Aβ, the development of tau proteins, and the occurrence of neuroinflammation and oxidative stress are associated with AD. However, investigations into the gut–brain axis (GBA) in the context of AD progression and pathology have yielded inconsistent findings. This review aims to enhance our understanding of microbial diversity at the species level and the role of these species in AD pathology. Additionally, this review addresses the influence of confounding elements, including diet, probiotics, and prebiotics, on AD throughout different stages (preclinical, mild cognitive impairment (MCI), and AD) of its progression.
Details
- Title
- The Role of Diet and Gut Microbiota in Alzheimer's Disease
- Authors/Creators
- D M Sithara Dissanayaka - Edith Cowan UniversityVijay Jayasena - Western Sydney UniversityStephanie R Rainey-Smith - Edith Cowan UniversityRalph N Martins - Macquarie UniversityW M A D Binosha Fernando - Edith Cowan University
- Publication Details
- Nutrients, Vol.16(3), 412
- Publisher
- MDPI
- Identifiers
- 991005637569907891
- Copyright
- © 2024 by the authors.
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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Highly Cited Paper
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.384 Gut Microbiota
- Web Of Science research areas
- Nutrition & Dietetics
- ESI research areas
- Agricultural Sciences