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Journal article
The Staphylococcus aureus Network Adaptive Platform Trial Protocol: New Tools for an Old Foe
Clinical Infectious Diseases, Vol.75(11), pp.2027-2034
2022
Abstract
Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with a 90-day mortality of 15%–30%. Despite this, <3000 people have been randomized into clinical trials of treatments for SAB infection. The limited evidence base partly results from clinical trials for SAB infections being difficult to complete at scale using traditional clinical trial methods. Here we provide the rationale and framework for an adaptive platform trial applied to SAB infections. We detail the design features of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial that will enable multiple questions to be answered as efficiently as possible. The SNAP trial commenced enrolling patients across multiple countries in 2022 with an estimated target sample size of 7000 participants. This approach may serve as an exemplar to increase efficiency of clinical trials for other infectious disease syndromes.
Details
- Title
- The Staphylococcus aureus Network Adaptive Platform Trial Protocol: New Tools for an Old Foe
- Authors/Creators
- S.Y.C. Tong (Author/Creator)J. Mora (Author/Creator)A.C. Bowen (Author/Creator)M.P. Cheng (Author/Creator)N. Daneman (Author/Creator)A.L. Goodman (Author/Creator)G.S. Heriot (Author/Creator)T.C. Lee (Author/Creator)R.J. Lewis (Author/Creator)D.C. Lye (Author/Creator)R.K. Mahar (Author/Creator)J. Marsh (Author/Creator)A. McGlothlin (Author/Creator)Z. McQuilten (Author/Creator)S.C. Morpeth (Author/Creator)D.L. Paterson (Author/Creator)D.J. Price (Author/Creator)J.A. Roberts (Author/Creator)J.O. Robinson (Author/Creator)S.J. van Hal (Author/Creator)G. Walls (Author/Creator)S.A. Webb (Author/Creator)L. Whiteway (Author/Creator)D. Yahav (Author/Creator)J.S. Davis (Author/Creator)N. Anagnostou (Author/Creator)S. Archuleta (Author/Creator)E. Athan (Author/Creator)E. Best (Author/Creator)M. Bloomfield (Author/Creator)C. Botheras (Author/Creator)A. Bowen (Author/Creator)P. Britton (Author/Creator)K. Brown (Author/Creator)A. Campbell (Author/Creator)H. Carter (Author/Creator)M. Cheng (Author/Creator)K.L. Chew (Author/Creator)R.L.M. Chong (Author/Creator)G. Coombs (Author/Creator)P. Daley (Author/Creator)N. Daneman (Author/Creator)J. Davies (Author/Creator)J. Davis (Author/Creator)Y. Dishon (Author/Creator)R. Dotel (Author/Creator)A. Dunlop (Author/Creator)F. Flack (Author/Creator)K. Flanagan (Author/Creator)H. Foo (Author/Creator)N. Ghanem-Zoubi (Author/Creator)S. Giulieri (Author/Creator)A. Goodman (Author/Creator)J. Grant (Author/Creator)D. Gregson (Author/Creator)S. Guy (Author/Creator)A. Gwee (Author/Creator)E. Hardy (Author/Creator)A. Henderson (Author/Creator)G. Heriot (Author/Creator)B. Howden (Author/Creator)J. Johnstone (Author/Creator)S. Kalimuddin (Author/Creator)D. de Kretser (Author/Creator)A. Kwa (Author/Creator)T. Lee (Author/Creator)A. Legg (Author/Creator)R. Lewis (Author/Creator)T. Lumley (Author/Creator)D. Lye (Author/Creator)D. MacFadden (Author/Creator)R. Mahar (Author/Creator)I. Malhamé (Author/Creator)M. Marks (Author/Creator)J. Marsh (Author/Creator)M. Martinello (Author/Creator)G. Matthews (Author/Creator)C. McArthur (Author/Creator)A. McGlothlin (Author/Creator)G. McKew (Author/Creator)B. McMullan (Author/Creator)Z. McQuilten (Author/Creator)E. Milliken (Author/Creator)J. Mora (Author/Creator)S. Morpeth (Author/Creator)S. Murthy (Author/Creator)C. Nourse (Author/Creator)M. O’Sullivan (Author/Creator)D. Paterson (Author/Creator)M. Paul (Author/Creator)N. Petersiel (Author/Creator)L. Petrella (Author/Creator)D. Price (Author/Creator)J. Roberts (Author/Creator)B. Rogers (Author/Creator)B. Saville (Author/Creator)M. Scheetz (Author/Creator)O. Scheuerman (Author/Creator)K. Schwartz (Author/Creator)S. Smith (Author/Creator)T. Snelling (Author/Creator)C. Sommerville (Author/Creator)A. Stewardson (Author/Creator)A. Sud (Author/Creator)S. Tong (Author/Creator)T. Turner (Author/Creator)S. van Hal (Author/Creator)N. Vasilunas (Author/Creator)L. Voss (Author/Creator)G. Walls (Author/Creator)R. Webb (Author/Creator)S. Webb (Author/Creator)L. Whiteway (Author/Creator)H. Wilson (Author/Creator)T. Wuerz (Author/Creator)D. Yahav (Author/Creator)
- Publication Details
- Clinical Infectious Diseases, Vol.75(11), pp.2027-2034
- Publisher
- Oxford University Press on behalf of Infectious Diseases Society of America
- Identifiers
- 991005545015407891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
- Note
- ...for the Staphylococcus aureus Network Adaptive Platform (SNAP) Study Group
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- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Microbiology
- ESI research areas
- Immunology