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The Synthesis of 4,6,8-Trimethoxy-1-naphthol. A New Approach
Journal article   Open access   Peer reviewed

The Synthesis of 4,6,8-Trimethoxy-1-naphthol. A New Approach

R.G.F. Giles, I.R. Green and V.I. Hugo
South African Journal of Chemistry, Vol.42(4), pp.162-163
1989
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Abstract

4,6,8-Trimethoxy-1-naphthol (1)1 is an important intermediate in the synthesis of a large number of naturally occurring oxygenated naphtho[2,3-c] pyranquinones. A key step in the formation of this material involves enolization and methylation of the enol ether (7) formed by a Diels-Alder reaction, followed by pyrolysis of the product (8).

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