Journal article
The association between mental illness, psychotropic medication use and hypertensive disorders in pregnancy: A multicentre study
Pregnancy Hypertension, Vol.24, pp.22-26
2021
Abstract
Objectives
Women with severe mental illnesses (SMI) may have elevated rates of hypertensive disorders in pregnancy (HDP) due to an accumulation of risk factors. This study aims to determine the prevalence rate of HPD within a population of women with SMI and to report on rates within different mental illness diagnoses and types of medication exposure.
Study design
A retrospective multicentre study of 521 pregnant women attending specialised antenatal clinics for the management of established SMI.
Main outcome measures
Measures included sociodemographic characteristics, pregnancy complications, mental health diagnosis and psychotropic medication use.
Results
Overall, 14% of women in the study had HDP. Compared to women with non-affective psychotic and other non-psychotic disorders (10.3%), women with depression and anxiety disorders demonstrated an increased risk of having a diagnosis of HDP (18.8%; RR = 1.82 [95% CI: 1.01, 3.29], p = .048). Log-binomial regression demonstrated that both a BMI in the overweight and obese range (RR = 3.37 [95% CI: 1.04, 10.95], p = .044) and continuous SNRI treatment throughout pregnancy (RR = 2.79 [95% CI; 1.33, 5.83], p = .006) were significant predictors of HDP, after adjusting for maternal age, gestational diabetes, and other mental health diagnoses.
Conclusion
Women with severe mental illnesses have elevated risk of developing HPD. Management remains complex and should address their comorbid risk profiles, and weigh up the risks and benefits of psychotropic medication use, given these results provide evidence of elevated rates of HDP associated with exposure to SNRI when taken throughout pregnancy.
Details
- Title
- The association between mental illness, psychotropic medication use and hypertensive disorders in pregnancy: A multicentre study
- Authors/Creators
- J. Frayne (Author/Creator) - King Edward Memorial HospitalS. Watson (Author/Creator) - The University of Notre Dame AustraliaM. Snellen (Author/Creator) - Mercy Hospital for WomenT. Nguyen (Author/Creator) - The University of Western AustraliaM. Galbally (Author/Creator) - King Edward Memorial Hospital
- Publication Details
- Pregnancy Hypertension, Vol.24, pp.22-26
- Publisher
- Elsevier BV
- Identifiers
- 991005544976607891
- Copyright
- © 2021 International Society for the Study of Hypertension in Pregnancy.
- Murdoch Affiliation
- School of Allied Health
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.72 Obstetrics & Gynecology
- 1.72.1072 Perinatal Mental Health
- Web Of Science research areas
- Obstetrics & Gynecology
- Peripheral Vascular Disease
- ESI research areas
- Clinical Medicine