Journal article
The association of regional white matter lesions with cognition in a community-based cohort of older individuals
NeuroImage: Clinical, Vol.19, pp.14-21
2018
Abstract
Emerging evidence from lesion-symptom mapping (LSM) studies suggested that regional white matter lesions (WML) on strategic white matter (WM) fiber tracts are significantly associated with specific cognitive domains, independent of global WML burden. However, previous LSM investigations were mostly carried out in disease cohorts, with little evidence from community-based older individuals, making findings difficult to generalize. Moreover, most LSM studies applied a threshold to the probabilistic atlas, leading to the loss of information and threshold-dependent findings. Furthermore, it is still unclear whether associations between regional WML and cognition are independent of global grey matter (GM) and WM volumes, which have also been linked to cognition. In the current study, we undertook a region of interest (ROI) LSM study to examine the relationship between regional WML on strategic WM tracts and cognitive performance in a large community-based cohort of older individuals (N = 461; 70–90 years). WML were extracted using a publicly available pipeline, UBO Detector (https://cheba.unsw.edu.au/group/neuroimaging-pipeline). Mapping of WML to the Johns Hopkins University WM atlas was undertaken using an automated TOolbox for Probabilistic MApping of Lesions (TOPMAL), which we introduce here, and is implemented in UBO Detector. The results show that different patterns of brain structural volumes in the ageing brain were associated with different cognitive domains. Regional WML were associated with processing speed, executive function, and global cognition, independent of total GM, WM and WML volumes. Moreover, regional WML explained more variance in executive function, compared to total GM, WM and WML volumes. The current study highlights the importance of studying regional WML in age-related cognitive decline.
Details
- Title
- The association of regional white matter lesions with cognition in a community-based cohort of older individuals
- Authors/Creators
- J. Jiang (Author/Creator)M. Paradise (Author/Creator)T. Liu (Author/Creator)N.J. Armstrong (Author/Creator)W. Zhu (Author/Creator)N.A. Kochan (Author/Creator)H. Brodaty (Author/Creator)P.S. Sachdev (Author/Creator)W. Wen (Author/Creator)
- Publication Details
- NeuroImage: Clinical, Vol.19, pp.14-21
- Publisher
- Elsevier Inc.
- Identifiers
- 991005545027107891
- Copyright
- © 2018 The Authors.
- Murdoch Affiliation
- School of Engineering and Information Technology
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Neuroimaging
- ESI research areas
- Neuroscience & Behavior