The bioactive compounds, beneficial medicinal properties, and biotechnological prospects of Fomitopsis : a comprehensive overview

Samantha C Karunarathna; Nimesha M Patabendige; Jaturong Kumla; Kalani K Hapuarachchi; Nakarin Suwannarach

doi:10.3389/fcimb.2025.1534617

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The bioactive compounds, beneficial medicinal properties, and biotechnological prospects of Fomitopsis : a comprehensive overview

Journal article

Open access

Peer reviewed

The bioactive compounds, beneficial medicinal properties, and biotechnological prospects of Fomitopsis : a comprehensive overview

Samantha C Karunarathna, Nimesha M Patabendige, Jaturong Kumla, Kalani K Hapuarachchi and Nakarin Suwannarach

Frontiers in cellular and infection microbiology, Vol.15, 1534617

2025

DOI: https://doi.org/10.3389/fcimb.2025.1534617

PMID: 40330023

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Abstract

Anti-Infective Agents - chemistry

Anti-Infective Agents - pharmacology

Anti-Inflammatory Agents - pharmacology

Antineoplastic Agents - pharmacology

Antioxidants - chemistry

Antioxidants - pharmacology

Biological Products - chemistry

Biological Products - pharmacology

Biotechnology - methods

Coriolaceae - chemistry

Coriolaceae - metabolism

Humans

Immunologic Factors - pharmacology

Phenols - chemistry

Phenols - pharmacology

Polysaccharides - chemistry

Polysaccharides - pharmacology

Secondary Metabolism

Terpenes - chemistry

Terpenes - isolation & purification

Terpenes - pharmacology

Members of the genus Fomitopsis are medicinal mushrooms and a rich source of bioactive compounds with significant pharmacological and biotechnological potential. This paper provides a comprehensive review of their secondary metabolites, including polysaccharides, terpenoids, and phenolic compounds. In addition, their chemical structures and biological activities are described in detail. These compounds exhibit antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory properties, with promising applications in cancer therapy, cardiovascular health, and immune modulation. Beyond medicine, Fomitopsis plays a crucial role in biotechnology, contributing to bioremediation, biofuel production, pharmaceutical development, and functional food innovation. By integrating traditional medicinal knowledge with recent scientific advances, this review highlights the biomedical significance and industrial relevance of Fomitopsis, underscoring its expanding role in health and environmental sustainability.

Details

Title: The bioactive compounds, beneficial medicinal properties, and biotechnological prospects of Fomitopsis : a comprehensive overview
Authors/Creators: Samantha C Karunarathna - Qujing Normal University
Nimesha M Patabendige - School of Medical, Molecular and Forensic Sciences, Murdoch University, Perth, WA, Australia
Jaturong Kumla - Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand
Kalani K Hapuarachchi - Southwest Forestry University
Nakarin Suwannarach - Chiang Mai University
Publication Details: Frontiers in cellular and infection microbiology, Vol.15, 1534617
Publisher: Frontiers Media SA
Number of pages: 32
Identifiers: 991005778129307891
Murdoch Affiliation: School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.698 Polysaccharide Bioactivities
Web Of Science research areas: Immunology; Microbiology
ESI research areas: Microbiology