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Author’s VersionCC BY-NC-ND V4.0, Open Access
Journal article
The bioavailability of medetomidine in eight sheep following oesophageal administration
Research in Veterinary Science, Vol.103, pp.137-142
2015
Abstract
There is sound evidence that medetomidine is an effective analgesic for acute pain in sheep. In this study, 15μgkg-1 of medetomidine was administered intravenously, and into the oesophagus, in a cross-over study, using eight sheep. Following intravenous administration, medetomidine could be detected in the plasma of these sheep for 120-180min but following oesophageal administration, medetomidine could not be detected in the plasma of any sheep at any of 17 time points over four days. It is suspected that this is due to high first pass metabolism in the liver. Consequently, we conclude that future studies investigating the use of analgesics in orally-administered osmotic pumps in sheep should consider higher doses of medetomidine (e.g. >100μgkg-1), further investigations into the barriers of medetomidine bioavailability from the sheep gut, liver-bypass drug delivery systems, or other α2-adrenergic agonists (e.g. clonidine or xylazine).
Details
- Title
- The bioavailability of medetomidine in eight sheep following oesophageal administration
- Authors/Creators
- T.H. Hyndman (Author/Creator) - Murdoch UniversityG.C. Musk (Author/Creator) - Murdoch UniversityF.R. Murdoch (Author/Creator) - School of Veterinary and Life Sciences, Murdoch University, Perth, Australia; Scottish Centre for Production Animal Health and Food Safety, School of Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.G.L. Maker (Author/Creator) - Murdoch UniversityT. Whittem (Author/Creator) - The University of Melbourne
- Publication Details
- Research in Veterinary Science, Vol.103, pp.137-142
- Publisher
- Elsevier
- Identifiers
- 991005544396207891
- Copyright
- © 2015 Elsevier Ltd.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- 1.43.1642 Veterinary Anesthesia
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