The cardiac L-type calcium channel alpha subunit is a target for direct redox modification during oxidative stress-the role of cysteine residues in the alpha interacting domain

P. Muralidharan; H. Cserne Szappanos; E. Ingley; L.C. Hool

doi:10.1111/1440-1681.12750

Back

The cardiac L-type calcium channel alpha subunit is a target for direct redox modification during oxidative stress-the role of cysteine residues in the alpha interacting domain

Journal article

Peer reviewed

The cardiac L-type calcium channel alpha subunit is a target for direct redox modification during oxidative stress-the role of cysteine residues in the alpha interacting domain

P. Muralidharan, H. Cserne Szappanos, E. Ingley and L.C. Hool

Clinical and Experimental Pharmacology and Physiology, Vol.44(S1), pp.46-54

2017

DOI: https://doi.org/10.1111/1440-1681.12750

Files and links (1)

url

Free to Read *No subscription requiredView

Abstract

Cardiovascular disease is the leading cause of death in the Western world. The incidence of cardiovascular disease is predicted to further rise with the increase in obesity and diabetes and with the aging population. Even though the survival rate from ischaemic heart disease has improved over the past 30 years, many patients progress to a chronic pathological condition, known as cardiac hypertrophy that is associated with an increase in morbidity and mortality. Reactive oxygen species (ROS) and calcium play an essential role in mediating cardiac hypertrophy. The L-type calcium channel is the main route for calcium influx into cardiac myocytes. There is now good evidence for a direct role for the L-type calcium channel in the development of cardiac hypertrophy. Cysteines on the channel are targets for redox modification and glutathionylation of the channel can modulate the function of the channel protein leading to the onset of pathology. The cysteine responsible for modification of L-type calcium channel function has now been identified. Detailed understanding of the role of cysteines as possible targets during oxidative stress may assist in designing therapy to prevent the development of hypertrophy and heart failure.

Details

Title: The cardiac L-type calcium channel alpha subunit is a target for direct redox modification during oxidative stress-the role of cysteine residues in the alpha interacting domain
Authors/Creators: P. Muralidharan (Author/Creator) - The University of Western Australia
H. Cserne Szappanos (Author/Creator)
E. Ingley (Author/Creator) - Harry Perkins Institute of Medical Research
L.C. Hool (Author/Creator) - The University of Western Australia
Publication Details: Clinical and Experimental Pharmacology and Physiology, Vol.44(S1), pp.46-54
Publisher: Wiley
Identifiers: 991005539987807891
Copyright: © 2017 John Wiley & Sons Australia, Ltd
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

27 Record Views

24 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.79 Molecular & Cell Biology - Physiology; 1.79.239 Ion Channelopathies
Web Of Science research areas: Pharmacology & Pharmacy; Physiology
ESI research areas: Pharmacology & Toxicology