Journal article
The chromosome‐level genome of female ginseng ( Angelica sinensis ) provides insights into molecular mechanisms and evolution of coumarin biosynthesis
The Plant Journal, Vol.112(5), pp.1224-1237
2022
Abstract
Coumarins are natural products with important medicinal values, and include simple coumarins, furanocoumarins and pyranocoumarins. Female ginseng (Angelica sinensis) is a renowned herb with abundant coumarins, originated in China and known for the treatment of female ailments for thousands of years. The molecular basis of simple coumarin biosynthesis in A. sinensis and the evolutionary history of the genes involved in furanocoumarin biosynthesis are largely unknown. Here, we generated the first chromosome-scale genome of A. sinensis. It has a genome size of 2.37 Gb, which was generated by combining PacBio and Hi-C sequencing technologies. The genome was predicted to contain 43 202 protein-coding genes dispersed mainly on 11 pseudochromosomes. We not only provided evidence for whole-genome duplication (WGD) specifically occurring in the Apioideae subfamily, but also demonstrated the vital role of tandem duplication for phenylpropanoid biosynthesis in A. sinensis. Combined analyses of transcriptomic and metabolomic data revealed key genes and candidate transcription factors regulating simple coumarin biosynthesis. Furthermore, phylogenomic synteny network analyses suggested prenyltransferase genes involved in furanocoumarin biosynthesis evolved independently in the Moraceae, Fabaceae, Rutaceae and Apiaceae after ζ and ε WGD. Our work sheds light on coumarin biosynthesis, and provides a benchmark for accelerating genetic research and molecular breeding in A. sinensis.
Details
- Title
- The chromosome‐level genome of female ginseng ( Angelica sinensis ) provides insights into molecular mechanisms and evolution of coumarin biosynthesis
- Authors/Creators
- X. Han (Author/Creator) - Agricultural Genomics Institute at ShenzhenC. Li (Author/Creator) - Agricultural Genomics Institute at ShenzhenS. Sun (Author/Creator) - Agricultural Genomics Institute at ShenzhenJ. Ji (Author/Creator) - Agricultural Genomics Institute at ShenzhenB. Nie (Author/Creator) - Agricultural Genomics Institute at ShenzhenG. Maker (Author/Creator) - Murdoch UniversityY. Ren (Author/Creator) - Murdoch UniversityL. Wang (Author/Creator) - Agricultural Genomics Institute at Shenzhen
- Publication Details
- The Plant Journal, Vol.112(5), pp.1224-1237
- Publisher
- Blackwell Publishing
- Identifiers
- 991005543849907891
- Copyright
- © 2022 Society for Experimental Biology and John Wiley & Sons Ltd.
- Murdoch Affiliation
- School of Agricultural Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.54 Molecular & Cell Biology - Genetics
- 1.54.1543 Flow Cytometry
- Web Of Science research areas
- Plant Sciences
- ESI research areas
- Plant & Animal Science