Journal article
The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis
Clinical & Translational Immunology, Vol.9(7), Art. e1153
2020
Abstract
Pulmonary fibrosis occurs in a heterogeneous group of lung disorders and is characterised by an excessive deposition of extracellular matrix proteins within the pulmonary interstitium, leading to impaired gas transfer and a loss of lung function. In the past 10 years, there has been a dramatic increase in our understanding of the immune system and how it contributes to fibrogenic processes within the lung. This review will compare some of the models used to investigate the pathogenesis and treatment of pulmonary fibrosis, in particular those used to study immune cell pathogenicity in idiopathic pulmonary fibrosis, highlighting their advantages and disadvantages in dissecting human disease.
Details
- Title
- The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis
- Authors/Creators
- T. Miles (Author/Creator)G.F. Hoyne (Author/Creator)D.A. Knight (Author/Creator)M.W. Fear (Author/Creator)S.E. Mutsaers (Author/Creator)C.M. Prêle (Author/Creator)
- Publication Details
- Clinical & Translational Immunology, Vol.9(7), Art. e1153
- Publisher
- John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology Inc
- Identifiers
- 991005541170507891
- Copyright
- © 2020 The Authors.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.208 Vasculitis & Autoimmune Disorders
- 1.208.1262 Idiopathic Pulmonary Fibrosis
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology