Journal article
The costs of human inbreeding and their implications for variations at the DNA level
Nature Genetics, Vol.8(2), pp.117-121
1994
Abstract
An analysis of the world literature on the children of first cousin marriages reveals that the depression of survival in offspring followed from birth (including late miscarriages; at about six months gestation or later) to a median age of 10 years is constant (4.4% plusminus 4.6) across a wide range of values for population prereproductive mortality. There is thus no evidence for the action of conditional lethals. On the basis of these data, it is calculated that the average human is heterozygous for only 1.4 lethal equivalents capable of acting over this portion of the life cycle. The implications of these results are discussed in the context of genetic counseling, and the biomedical significance of variation in DNA.
Details
- Title
- The costs of human inbreeding and their implications for variations at the DNA level
- Authors/Creators
- A.H. Bittles (Author/Creator) - Edith Cowan UniversityJ.V. Neel (Author/Creator) - University of Michigan
- Publication Details
- Nature Genetics, Vol.8(2), pp.117-121
- Publisher
- Nature Publishing Group
- Identifiers
- 991005542790107891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.189 Genome Studies
- 1.189.1853 Human Genetic Diversity
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics