Journal article
The culture of human cleavage stage embryos alone or in groups: effect upon blastocyst utilization rates and implantation
Reproductive Biology, Vol.10(3), pp.227-234
2010
Abstract
The effect of cleavage-stage group culture (CGC; embryos cultured in groups of three or more for the first 3 days and then individually to blastocyst) was compared to extended single embryo culture (ESC; embryos cultured individually to the blastocyst stage). While implantation and ongoing pregnancy rates were similar between groups, the blastocyst utilization rate (number of blastocysts suitable for freezing and thawing/total number of embryos cultured to Day 5 and 6) was significantly higher when embryos were cultured in CGC for women <35 yrs thereby increasing the number of embryos available for clinical use for the younger women. This strategy of group culture to Day 3 would seem an ideal protocol to capitalize on an overall embryo quality in two particular settings, namely programmes wishing to (i) undertake Day 3 transfers, and (ii) keep embryos separate from Day 3 to Day5/6 for the purposes of selection. The culture system can also be applied to the embryos of older women without adverse effect, enabling the same system to be used for all embryos.
Details
- Title
- The culture of human cleavage stage embryos alone or in groups: effect upon blastocyst utilization rates and implantation
- Authors/Creators
- I. Rebollar-Lazaro (Author/Creator)P. Matson (Author/Creator)
- Publication Details
- Reproductive Biology, Vol.10(3), pp.227-234
- Publisher
- Polish Society for Biology of Reproduction
- Number of pages
- 8
- Identifiers
- 991005542516507891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.81 Reproductive Biology
- 1.81.339 Embryo Development
- Web Of Science research areas
- Reproductive Biology
- ESI research areas
- Clinical Medicine