The culture of human cleavage stage embryos alone or in groups: effect upon blastocyst utilization rates and implantation

I. Rebollar-Lazaro; P. Matson

doi:10.1016/S1642-431X(12)60042-4

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The culture of human cleavage stage embryos alone or in groups: effect upon blastocyst utilization rates and implantation

Journal article

Peer reviewed

The culture of human cleavage stage embryos alone or in groups: effect upon blastocyst utilization rates and implantation

I. Rebollar-Lazaro and P. Matson

Reproductive Biology, Vol.10(3), pp.227-234

2010

DOI: https://doi.org/10.1016/S1642-431X(12)60042-4

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Abstract

human

embryo

group culture

The effect of cleavage-stage group culture (CGC; embryos cultured in groups of three or more for the first 3 days and then individually to blastocyst) was compared to extended single embryo culture (ESC; embryos cultured individually to the blastocyst stage). While implantation and ongoing pregnancy rates were similar between groups, the blastocyst utilization rate (number of blastocysts suitable for freezing and thawing/total number of embryos cultured to Day 5 and 6) was significantly higher when embryos were cultured in CGC for women <35 yrs thereby increasing the number of embryos available for clinical use for the younger women. This strategy of group culture to Day 3 would seem an ideal protocol to capitalize on an overall embryo quality in two particular settings, namely programmes wishing to (i) undertake Day 3 transfers, and (ii) keep embryos separate from Day 3 to Day5/6 for the purposes of selection. The culture system can also be applied to the embryos of older women without adverse effect, enabling the same system to be used for all embryos.

Details

Title: The culture of human cleavage stage embryos alone or in groups: effect upon blastocyst utilization rates and implantation
Authors/Creators: I. Rebollar-Lazaro (Author/Creator)
P. Matson (Author/Creator)
Publication Details: Reproductive Biology, Vol.10(3), pp.227-234
Publisher: Polish Society for Biology of Reproduction
Number of pages: 8
Identifiers: 991005542516507891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.81 Reproductive Biology; 1.81.339 Embryo Development
Web Of Science research areas: Reproductive Biology
ESI research areas: Clinical Medicine