The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy

S. Lee; A. Laiman; M.A French; J. Flexman; M.W. Watson; P. Price

doi:10.1016/j.clim.2017.03.005

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The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy

Journal article

Open access

Peer reviewed

The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy

S. Lee, A. Laiman, M.A French, J. Flexman, M.W. Watson and P. Price

Clinical Immunology, Vol.179, pp.54-63

2017

DOI: https://doi.org/10.1016/j.clim.2017.03.005

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Abstract

Antibody responses have not been fully characterised in chronically HIV/HCV patients receiving antiretroviral therapy (ART). Seventeen HIV/HCV patients receiving ART were followed for a median (range) interval of 597 (186–766) weeks. Prior to ART, HIV/HCV patients had lower levels of antibodies reactive with HCV core and JFH-1, and lower genotype cross-reactive neutralising antibodies (nAb) titres, than HCV patients. Levels of JFH-1 reactive antibody increased on ART, irrespective of CD4+ T-cell counts or changes in serum ALT levels. The appearance of nAb coincided with control of HCV viral replication in five HIV/HCV patients. In other patients, HCV viral loads remained elevated despite nAb responses. Sustained virological responses following HCV therapy were associated with reduced antibody responses to JFH-1 and core but elevated responses to non-structural proteins. We conclude that nAb responses alone may fail to clear HCV, but contribute to control of viral replication in some HIV/HCV patients responding to ART.

Details

Title: The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy
Authors/Creators: S. Lee (Author/Creator) - Royal Perth Hospital
A. Laiman (Author/Creator) - The University of Western Australia
M.A French (Author/Creator) - The University of Western Australia
J. Flexman (Author/Creator) - Royal Perth Hospital
M.W. Watson (Author/Creator) - Murdoch University
P. Price (Author/Creator) - Curtin University
Publication Details: Clinical Immunology, Vol.179, pp.54-63
Publisher: Academic Press Inc.
Identifiers: 991005542938607891
Copyright: © 2017 Elsevier Inc.
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.125 Hepatitis; 1.125.83 HCV
Web Of Science research areas: Immunology
ESI research areas: Immunology