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The effect of copper and heliotrope on the composition of bile in sheep
Journal article   Peer reviewed

The effect of copper and heliotrope on the composition of bile in sheep

H.S. Deol, J.Mc.C. Howell, P.R. Dorling and H.W. Symonds
Research in Veterinary Science, Vol.53(3), pp.324-330
1992
DOI: https://doi.org/10.1016/0034-5288(92)90134-N
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Abstract

The effects of interrupting the enterohepatic circulation (ehc) of bile salts for seven hours and of feeding copper and heliotrope alone and combined for 13 weeks, on bile flow and excretion of copper, zinc, iron and α-mannosidase were studied in sheep. Interruption of ehc reduced bile flow rate and increased the concentration of copper, zinc, iron and bile acids while α-mannosidase's activity remained stable. Changes in concentration were related to changes in bile volume for copper and zinc only. Total output per hour was not changed. Biliary concentration of copper correlated with α-mannosidase's activity in control sheep and those given copper or heliotrope, supporting the hypothesis that lysosomes are involved in biliary secretion of copper in sheep. Increasing the intake of copper increased the rate of excretion of copper in bile. Copper output was lower when heliotrope was fed alone.

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Source: InCites

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35 Record Views
2 Times Cited - Web of Science

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Collaboration types
Domestic collaboration
International collaboration
Citation topics
1 Clinical & Life Sciences
1.184 Physiology & Metals
1.184.653 Zinc Nutrition
Web Of Science research areas
Veterinary Sciences
ESI research areas
Plant & Animal Science
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